Phosphorylation of CLIP-170 by LRRK1 regulates EGFR trafficking by promoting recruitment of p150Glued to MT plus-ends
Ligand-induced activation of the EGF receptor (EGFR) initiates trafficking events that relocalize the receptors from the cell surface to intracellular endocytic compartments. Early endosomes containing activated EGFR migrate along microtubules as they mature into late endosomes. We have recently sho...
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| Published in | Journal of cell science |
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| Language | English |
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01.01.2014
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| Abstract | Ligand-induced activation of the EGF receptor (EGFR) initiates trafficking events that relocalize the receptors from the cell surface to intracellular endocytic compartments. Early endosomes containing activated EGFR migrate along microtubules as they mature into late endosomes. We have recently shown that LRRK1, which is related to the familial Parkinsonism gene product Park8/LRRK2, regulates this EGFR transport in a manner dependent on LRRK1 kinase activity. However, the downstream targets of LRRK1 that may modulate this transport function have not been identified. Here, we identify CLIP-170, a microtubule plus-end protein, as a substrate of LRRK1. LRRK1 phosphorylates CLIP-170 at Thr-1384, located in its C-terminal zinc knuckle motif, and this promotes its association with dynactin–dynein complexes. We find that LRRK1 phosphorylation of CLIP-170 causes the accumulation of p150Glued, a subunit of dynactin, at microtubule plus-ends, thereby facilitating the migration of EGFR-containing endosomes. Thus, our findings provide new mechanistic insights into the dynein-driven transport of EGFR. |
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| AbstractList | Ligand-induced activation of the EGF receptor (EGFR) initiates trafficking events that relocalize the receptors from the cell surface to intracellular endocytic compartments. Early endosomes containing activated EGFR migrate along microtubules as they mature into late endosomes. We have recently shown that LRRK1, which is related to the familial Parkinsonism gene product Park8/LRRK2, regulates this EGFR transport in a manner dependent on LRRK1 kinase activity. However, the downstream targets of LRRK1 that may modulate this transport function have not been identified. Here, we identify CLIP-170, a microtubule plus-end protein, as a substrate of LRRK1. LRRK1 phosphorylates CLIP-170 at Thr-1384, located in its C-terminal zinc knuckle motif, and this promotes its association with dynactin–dynein complexes. We find that LRRK1 phosphorylation of CLIP-170 causes the accumulation of p150Glued, a subunit of dynactin, at microtubule plus-ends, thereby facilitating the migration of EGFR-containing endosomes. Thus, our findings provide new mechanistic insights into the dynein-driven transport of EGFR. |
| Author | Watanabe, Takashi Matsumoto, Kunihiro Kedashiro, Shin Hanafusa, Hiroshi Pastuhov, Strahil I. Nishioka, Tomoki Kaibuchi, Kozo |
| Author_xml | – sequence: 1 givenname: Shin surname: Kedashiro fullname: Kedashiro, Shin – sequence: 2 givenname: Strahil I. surname: Pastuhov fullname: Pastuhov, Strahil I. – sequence: 3 givenname: Tomoki surname: Nishioka fullname: Nishioka, Tomoki – sequence: 4 givenname: Takashi surname: Watanabe fullname: Watanabe, Takashi – sequence: 5 givenname: Kozo surname: Kaibuchi fullname: Kaibuchi, Kozo – sequence: 6 givenname: Kunihiro surname: Matsumoto fullname: Matsumoto, Kunihiro – sequence: 7 givenname: Hiroshi surname: Hanafusa fullname: Hanafusa, Hiroshi |
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| Cites_doi | 10.1038/nature08910 10.1083/jcb.200608128 10.1523/JNEUROSCI.0935-13.2013 10.1083/jcb.200402082 10.1091/mbc.E09-12-1036 10.1038/312237a0 10.1074/jbc.M109.017681 10.1016/S0092-8674(02)00800-0 10.1016/j.ceb.2004.06.005 10.1016/j.ceb.2008.04.001 10.1016/j.neuron.2012.02.025 10.1042/BST0391179 10.1038/emboj.2010.174 10.1016/j.bbamcr.2003.08.008 10.1074/jbc.M804840200 10.1111/j.1600-0854.2006.00400.x 10.1083/jcb.200201029 10.1016/0092-8674(86)90318-1 10.1093/embo-reports/kvf197 10.1146/annurev.cellbio.20.012103.094623 10.1083/jcb.200208058 10.1016/j.ceb.2010.04.008 10.1016/j.ceb.2004.11.001 10.1038/nrm1962 10.1016/j.cell.2010.06.011 10.1038/nsmb1299 10.1016/S0092-8674(00)80656-X 10.1242/jcs.02999 10.1038/ncb1525 10.1016/0092-8674(92)90240-D 10.1038/nrm973 10.1038/sj.onc.1202247 10.1016/j.tcb.2013.11.002 10.1038/nrm2748 10.1038/nsmb1291 10.1038/nrm2369 10.1038/ncomms1161 10.1016/j.tcb.2004.07.011 10.1091/mbc.E11-09-0780 10.1083/jcb.200809190 10.1038/nrm2804 10.1016/j.devcel.2009.07.010 10.1016/j.neuron.2012.02.026 10.1242/jcs.050260 10.1016/j.ceb.2011.03.008 10.1016/j.tcb.2006.01.004 10.1091/mbc.10.12.4107 10.1016/S0021-9258(19)47414-0 10.1038/nrm1664 10.1038/ncb2060 10.1038/nrm2060 10.1242/jcs.112.10.1437 10.1091/mbc.E02-03-0155 10.1016/j.tcb.2006.08.002 |
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| References | Kirschner (2021042614435979200_b20) 1986; 45 Hanafusa (2021042614435979200_b13) 2011; 2 Miaczynska (2021042614435979200_b31) 2004; 16 Akhmanova (2021042614435979200_b1) 2010; 22 Dixit (2021042614435979200_b9) 2008; 283 Galjart (2021042614435979200_b12) 2005; 6 Perez (2021042614435979200_b37) 1999; 96 Lloyd (2021042614435979200_b28) 2012; 74 Lomakin (2021042614435979200_b29) 2009; 17 Choi (2021042614435979200_b7) 2002; 3 Platta (2021042614435979200_b39) 2011; 23 Weisbrich (2021042614435979200_b51) 2007; 14 Vaughan (2021042614435979200_b49) 2002; 158 Yang (2021042614435979200_b54) 2009; 284 Wu (2021042614435979200_b53) 2006; 16 Morrison (2021042614435979200_b33) 1998; 17 Mitchison (2021042614435979200_b32) 1984; 312 Valetti (2021042614435979200_b46) 1999; 10 Ishikawa (2021042614435979200_b16) 2012; 23 Lansbergen (2021042614435979200_b22) 2006; 7 Lee (2021042614435979200_b24) 2010; 21 Madshus (2021042614435979200_b30) 2009; 122 Driskell (2021042614435979200_b10) 2007; 9 Schroer (2021042614435979200_b41) 2004; 20 Watson (2021042614435979200_b50) 2006; 119 Vaughan (2021042614435979200_b48) 1999; 112 Fukata (2021042614435979200_b11) 2002; 109 Hayashi (2021042614435979200_b14) 2007; 14 Ligon (2021042614435979200_b27) 2003; 14 Sorkin (2021042614435979200_b44) 2009; 10 Woodman (2021042614435979200_b52) 2008; 20 Rickard (2021042614435979200_b40) 1991; 266 Bieling (2021042614435979200_b4) 2008; 183 Li (2021042614435979200_b26) 2010; 29 Soldati (2021042614435979200_b43) 2006; 7 Moughamian (2021042614435979200_b35) 2013; 33 Bosgraaf (2021042614435979200_b5) 2003; 1643 Vaughan (2021042614435979200_b47) 2004; 14 Katzmann (2021042614435979200_b18) 2002; 3 Akhmanova (2021042614435979200_b2) 2005; 17 Hunt (2021042614435979200_b15) 2011; 39 Caviston (2021042614435979200_b6) 2006; 16 Lemmon (2021042614435979200_b25) 2010; 141 Moughamian (2021042614435979200_b34) 2012; 74 Kim (2021042614435979200_b19) 2007; 176 Scita (2021042614435979200_b42) 2010; 463 Tomas (2021042614435979200_b45) 2014; 24 Akhmanova (2021042614435979200_b3) 2008; 9 Citri (2021042614435979200_b8) 2006; 7 Nakano (2021042614435979200_b36) 2010; 12 Pierre (2021042614435979200_b38) 1992; 70 Kardon (2021042614435979200_b17) 2009; 10 Komarova (2021042614435979200_b21) 2002; 159 Lansbergen (2021042614435979200_b23) 2004; 166 |
| References_xml | – volume: 463 start-page: 464 year: 2010 ident: 2021042614435979200_b42 article-title: The endocytic matrix. publication-title: Nature doi: 10.1038/nature08910 contributor: fullname: Scita – volume: 176 start-page: 641 year: 2007 ident: 2021042614435979200_b19 article-title: Microtubule binding by dynactin is required for microtubule organization but not cargo transport. publication-title: J. Cell Biol. doi: 10.1083/jcb.200608128 contributor: fullname: Kim – volume: 33 start-page: 13190 year: 2013 ident: 2021042614435979200_b35 article-title: Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport. publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0935-13.2013 contributor: fullname: Moughamian – volume: 166 start-page: 1003 year: 2004 ident: 2021042614435979200_b23 article-title: Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. publication-title: J. Cell Biol. doi: 10.1083/jcb.200402082 contributor: fullname: Lansbergen – volume: 21 start-page: 2661 year: 2010 ident: 2021042614435979200_b24 article-title: Phosphorylation controls autoinhibition of cytoplasmic linker protein-170. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E09-12-1036 contributor: fullname: Lee – volume: 312 start-page: 237 year: 1984 ident: 2021042614435979200_b32 article-title: Dynamic instability of microtubule growth. publication-title: Nature doi: 10.1038/312237a0 contributor: fullname: Mitchison – volume: 284 start-page: 28775 year: 2009 ident: 2021042614435979200_b54 article-title: Cdc2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.017681 contributor: fullname: Yang – volume: 109 start-page: 873 year: 2002 ident: 2021042614435979200_b11 article-title: Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. publication-title: Cell doi: 10.1016/S0092-8674(02)00800-0 contributor: fullname: Fukata – volume: 16 start-page: 400 year: 2004 ident: 2021042614435979200_b31 article-title: Not just a sink: endosomes in control of signal transduction. publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2004.06.005 contributor: fullname: Miaczynska – volume: 20 start-page: 408 year: 2008 ident: 2021042614435979200_b52 article-title: Multivesicular bodies: co-ordinated progression to maturity. publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2008.04.001 contributor: fullname: Woodman – volume: 74 start-page: 331 year: 2012 ident: 2021042614435979200_b34 article-title: Dynactin is required for transport initiation from the distal axon. publication-title: Neuron doi: 10.1016/j.neuron.2012.02.025 contributor: fullname: Moughamian – volume: 39 start-page: 1179 year: 2011 ident: 2021042614435979200_b15 article-title: The role of motor proteins in endosomal sorting. publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0391179 contributor: fullname: Hunt – volume: 29 start-page: 2953 year: 2010 ident: 2021042614435979200_b26 article-title: Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments. publication-title: EMBO J. doi: 10.1038/emboj.2010.174 contributor: fullname: Li – volume: 1643 start-page: 5 year: 2003 ident: 2021042614435979200_b5 article-title: Roc, a Ras/GTPase domain in complex proteins. publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2003.08.008 contributor: fullname: Bosgraaf – volume: 283 start-page: 33611 year: 2008 ident: 2021042614435979200_b9 article-title: Regulation of dynactin through the differential expression of p150Glued isoforms. publication-title: J. Biol. Chem. doi: 10.1074/jbc.M804840200 contributor: fullname: Dixit – volume: 7 start-page: 499 year: 2006 ident: 2021042614435979200_b22 article-title: Microtubule plus end: a hub of cellular activities. publication-title: Traffic doi: 10.1111/j.1600-0854.2006.00400.x contributor: fullname: Lansbergen – volume: 158 start-page: 305 year: 2002 ident: 2021042614435979200_b49 article-title: A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport. publication-title: J. Cell Biol. doi: 10.1083/jcb.200201029 contributor: fullname: Vaughan – volume: 45 start-page: 329 year: 1986 ident: 2021042614435979200_b20 article-title: Beyond self-assembly: from microtubules to morphogenesis. publication-title: Cell doi: 10.1016/0092-8674(86)90318-1 contributor: fullname: Kirschner – volume: 3 start-page: 988 year: 2002 ident: 2021042614435979200_b7 article-title: The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. publication-title: EMBO Rep. doi: 10.1093/embo-reports/kvf197 contributor: fullname: Choi – volume: 20 start-page: 759 year: 2004 ident: 2021042614435979200_b41 article-title: Dynactin. publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.20.012103.094623 contributor: fullname: Schroer – volume: 159 start-page: 589 year: 2002 ident: 2021042614435979200_b21 article-title: Cytoplasmic linker proteins promote microtubule rescue in vivo. publication-title: J. Cell Biol. doi: 10.1083/jcb.200208058 contributor: fullname: Komarova – volume: 22 start-page: 479 year: 2010 ident: 2021042614435979200_b1 article-title: Linking molecular motors to membrane cargo. publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2010.04.008 contributor: fullname: Akhmanova – volume: 17 start-page: 47 year: 2005 ident: 2021042614435979200_b2 article-title: Microtubule plus-end-tracking proteins: mechanisms and functions. publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2004.11.001 contributor: fullname: Akhmanova – volume: 7 start-page: 505 year: 2006 ident: 2021042614435979200_b8 article-title: EGF-ERBB signalling: towards the systems level. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1962 contributor: fullname: Citri – volume: 141 start-page: 1117 year: 2010 ident: 2021042614435979200_b25 article-title: Cell signaling by receptor tyrosine kinases. publication-title: Cell doi: 10.1016/j.cell.2010.06.011 contributor: fullname: Lemmon – volume: 14 start-page: 980 year: 2007 ident: 2021042614435979200_b14 article-title: CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1. publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb1299 contributor: fullname: Hayashi – volume: 96 start-page: 517 year: 1999 ident: 2021042614435979200_b37 article-title: CLIP-170 highlights growing microtubule ends in vivo. publication-title: Cell doi: 10.1016/S0092-8674(00)80656-X contributor: fullname: Perez – volume: 119 start-page: 2758 year: 2006 ident: 2021042614435979200_b50 article-title: Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells. publication-title: J. Cell Sci. doi: 10.1242/jcs.02999 contributor: fullname: Watson – volume: 9 start-page: 113 year: 2007 ident: 2021042614435979200_b10 article-title: Dynein is required for receptor sorting and the morphogenesis of early endosomes. publication-title: Nat. Cell Biol. doi: 10.1038/ncb1525 contributor: fullname: Driskell – volume: 70 start-page: 887 year: 1992 ident: 2021042614435979200_b38 article-title: CLIP-170 links endocytic vesicles to microtubules. publication-title: Cell doi: 10.1016/0092-8674(92)90240-D contributor: fullname: Pierre – volume: 3 start-page: 893 year: 2002 ident: 2021042614435979200_b18 article-title: Receptor downregulation and multivesicular-body sorting. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm973 contributor: fullname: Katzmann – volume: 17 start-page: 3471 year: 1998 ident: 2021042614435979200_b33 article-title: EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. publication-title: Oncogene doi: 10.1038/sj.onc.1202247 contributor: fullname: Morrison – volume: 24 start-page: 26 year: 2014 ident: 2021042614435979200_b45 article-title: EGF receptor trafficking: consequences for signaling and cancer. publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2013.11.002 contributor: fullname: Tomas – volume: 10 start-page: 609 year: 2009 ident: 2021042614435979200_b44 article-title: Endocytosis and signalling: intertwining molecular networks. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2748 contributor: fullname: Sorkin – volume: 14 start-page: 959 year: 2007 ident: 2021042614435979200_b51 article-title: Structure-function relationship of CAP-Gly domains. publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb1291 contributor: fullname: Weisbrich – volume: 9 start-page: 309 year: 2008 ident: 2021042614435979200_b3 article-title: Tracking the ends: a dynamic protein network controls the fate of microtubule tips. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2369 contributor: fullname: Akhmanova – volume: 2 start-page: 158 year: 2011 ident: 2021042614435979200_b13 article-title: Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. publication-title: Nat. Commun. doi: 10.1038/ncomms1161 contributor: fullname: Hanafusa – volume: 14 start-page: 491 year: 2004 ident: 2021042614435979200_b47 article-title: Surfing, regulating and capturing: are all microtubule-tip-tracking proteins created equal? publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2004.07.011 contributor: fullname: Vaughan – volume: 23 start-page: 1294 year: 2012 ident: 2021042614435979200_b16 article-title: EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E11-09-0780 contributor: fullname: Ishikawa – volume: 183 start-page: 1223 year: 2008 ident: 2021042614435979200_b4 article-title: CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites. publication-title: J. Cell Biol. doi: 10.1083/jcb.200809190 contributor: fullname: Bieling – volume: 10 start-page: 854 year: 2009 ident: 2021042614435979200_b17 article-title: Regulators of the cytoplasmic dynein motor. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2804 contributor: fullname: Kardon – volume: 17 start-page: 323 year: 2009 ident: 2021042614435979200_b29 article-title: CLIP-170-dependent capture of membrane organelles by microtubules initiates minus-end directed transport. publication-title: Dev. Cell doi: 10.1016/j.devcel.2009.07.010 contributor: fullname: Lomakin – volume: 74 start-page: 344 year: 2012 ident: 2021042614435979200_b28 article-title: The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini. publication-title: Neuron doi: 10.1016/j.neuron.2012.02.026 contributor: fullname: Lloyd – volume: 122 start-page: 3433 year: 2009 ident: 2021042614435979200_b30 article-title: Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking. publication-title: J. Cell Sci. doi: 10.1242/jcs.050260 contributor: fullname: Madshus – volume: 23 start-page: 393 year: 2011 ident: 2021042614435979200_b39 article-title: Endocytosis and signaling. publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2011.03.008 contributor: fullname: Platta – volume: 16 start-page: 135 year: 2006 ident: 2021042614435979200_b53 article-title: Motor proteins at the microtubule plus-end. publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2006.01.004 contributor: fullname: Wu – volume: 10 start-page: 4107 year: 1999 ident: 2021042614435979200_b46 article-title: Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.10.12.4107 contributor: fullname: Valetti – volume: 266 start-page: 17597 year: 1991 ident: 2021042614435979200_b40 article-title: Binding of pp170 to microtubules is regulated by phosphorylation. publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)47414-0 contributor: fullname: Rickard – volume: 6 start-page: 487 year: 2005 ident: 2021042614435979200_b12 article-title: CLIPs and CLASPs and cellular dynamics. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1664 contributor: fullname: Galjart – volume: 12 start-page: 583 year: 2010 ident: 2021042614435979200_b36 article-title: AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. publication-title: Nat. Cell Biol. doi: 10.1038/ncb2060 contributor: fullname: Nakano – volume: 7 start-page: 897 year: 2006 ident: 2021042614435979200_b43 article-title: Powering membrane traffic in endocytosis and recycling. publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2060 contributor: fullname: Soldati – volume: 112 start-page: 1437 year: 1999 ident: 2021042614435979200_b48 article-title: Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends. publication-title: J. Cell Sci. doi: 10.1242/jcs.112.10.1437 contributor: fullname: Vaughan – volume: 14 start-page: 1405 year: 2003 ident: 2021042614435979200_b27 article-title: The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization. publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E02-03-0155 contributor: fullname: Ligon – volume: 16 start-page: 530 year: 2006 ident: 2021042614435979200_b6 article-title: Microtubule motors at the intersection of trafficking and transport. publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2006.08.002 contributor: fullname: Caviston |
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