Differential Impact of Age and Cytomegalovirus Infection on the γδ T Cell Compartment
γδ T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the γδ T cell comp...
Saved in:
| Published in | The Journal of immunology (1950) Vol. 191; no. 3; pp. 1300 - 1306 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists
01.08.2013
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-1767 1550-6606 1550-6606 |
| DOI | 10.4049/jimmunol.1202940 |
Cover
Loading…
| Abstract | γδ T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the γδ T cell compartment with advanced age in humans. We show that both aging and CMV infection impact independently on the γδ T cell compartment. Most γδ T cells are significantly affected by age and present a decreased frequency in the elderly. The decline of the γδ T cell pool appears to be independent from the activity of the thymus, arguing in favor of an extrathymic site of γδ T cell production in humans. Of note, CMV infection, which is directly associated with the activation of the pool of Vδ2− γδ T cells, promotes nonetheless the inflation of this compartment throughout life. CMV seropositivity accentuates further the accumulation of highly differentiated lymphocytes in Vδ2− γδ T cell subsets with time, in contrast to Vδ2+ γδ T cells, which maintain a less differentiated phenotype. This is similar to the effect of CMV on αβ T cells and suggests that γδ T cells may vary in differentiation phenotype according to distinct stimuli or pathogens. |
|---|---|
| AbstractList | γδ T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the γδ T cell compartment with advanced age in humans. We show that both aging and CMV infection impact independently on the γδ T cell compartment. Most γδ T cells are significantly affected by age and present a decreased frequency in the elderly. The decline of the γδ T cell pool appears to be independent from the activity of the thymus, arguing in favor of an extrathymic site of γδ T cell production in humans. Of note, CMV infection, which is directly associated with the activation of the pool of Vδ2(-) γδ T cells, promotes nonetheless the inflation of this compartment throughout life. CMV seropositivity accentuates further the accumulation of highly differentiated lymphocytes in Vδ2(-) γδ T cell subsets with time, in contrast to Vδ2(+) γδ T cells, which maintain a less differentiated phenotype. This is similar to the effect of CMV on αβ T cells and suggests that γδ T cells may vary in differentiation phenotype according to distinct stimuli or pathogens. γδ T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the γδ T cell compartment with advanced age in humans. We show that both aging and CMV infection impact independently on the γδ T cell compartment. Most γδ T cells are significantly affected by age and present a decreased frequency in the elderly. The decline of the γδ T cell pool appears to be independent from the activity of the thymus, arguing in favor of an extrathymic site of γδ T cell production in humans. Of note, CMV infection, which is directly associated with the activation of the pool of Vδ2(-) γδ T cells, promotes nonetheless the inflation of this compartment throughout life. CMV seropositivity accentuates further the accumulation of highly differentiated lymphocytes in Vδ2(-) γδ T cell subsets with time, in contrast to Vδ2(+) γδ T cells, which maintain a less differentiated phenotype. This is similar to the effect of CMV on αβ T cells and suggests that γδ T cells may vary in differentiation phenotype according to distinct stimuli or pathogens.γδ T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the γδ T cell compartment with advanced age in humans. We show that both aging and CMV infection impact independently on the γδ T cell compartment. Most γδ T cells are significantly affected by age and present a decreased frequency in the elderly. The decline of the γδ T cell pool appears to be independent from the activity of the thymus, arguing in favor of an extrathymic site of γδ T cell production in humans. Of note, CMV infection, which is directly associated with the activation of the pool of Vδ2(-) γδ T cells, promotes nonetheless the inflation of this compartment throughout life. CMV seropositivity accentuates further the accumulation of highly differentiated lymphocytes in Vδ2(-) γδ T cell subsets with time, in contrast to Vδ2(+) γδ T cells, which maintain a less differentiated phenotype. This is similar to the effect of CMV on αβ T cells and suggests that γδ T cells may vary in differentiation phenotype according to distinct stimuli or pathogens. γδ T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate mediators between adaptive and innate immunity. We provide in this paper further insights underlying the changes that affect the γδ T cell compartment with advanced age in humans. We show that both aging and CMV infection impact independently on the γδ T cell compartment. Most γδ T cells are significantly affected by age and present a decreased frequency in the elderly. The decline of the γδ T cell pool appears to be independent from the activity of the thymus, arguing in favor of an extrathymic site of γδ T cell production in humans. Of note, CMV infection, which is directly associated with the activation of the pool of Vδ2− γδ T cells, promotes nonetheless the inflation of this compartment throughout life. CMV seropositivity accentuates further the accumulation of highly differentiated lymphocytes in Vδ2− γδ T cell subsets with time, in contrast to Vδ2+ γδ T cells, which maintain a less differentiated phenotype. This is similar to the effect of CMV on αβ T cells and suggests that γδ T cells may vary in differentiation phenotype according to distinct stimuli or pathogens. |
| Author | Stern, Marc Larsen, Martin Urrutia, Alejandra Gorochov, Guy Sauce, Delphine Sibony-Prat, Joyce Donner, Catherine Autran, Brigitte Fastenackels, Solène Sidi, Daniel Marchant, Arnaud Appay, Victor Roux, Antoine Mourin, Gisèle |
| Author_xml | – sequence: 1 givenname: Antoine surname: Roux fullname: Roux, Antoine – sequence: 2 givenname: Gisèle surname: Mourin fullname: Mourin, Gisèle – sequence: 3 givenname: Martin surname: Larsen fullname: Larsen, Martin – sequence: 4 givenname: Solène surname: Fastenackels fullname: Fastenackels, Solène – sequence: 5 givenname: Alejandra surname: Urrutia fullname: Urrutia, Alejandra – sequence: 6 givenname: Guy surname: Gorochov fullname: Gorochov, Guy – sequence: 7 givenname: Brigitte surname: Autran fullname: Autran, Brigitte – sequence: 8 givenname: Catherine surname: Donner fullname: Donner, Catherine – sequence: 9 givenname: Daniel surname: Sidi fullname: Sidi, Daniel – sequence: 10 givenname: Joyce surname: Sibony-Prat fullname: Sibony-Prat, Joyce – sequence: 11 givenname: Arnaud surname: Marchant fullname: Marchant, Arnaud – sequence: 12 givenname: Marc surname: Stern fullname: Stern, Marc – sequence: 13 givenname: Delphine surname: Sauce fullname: Sauce, Delphine – sequence: 14 givenname: Victor surname: Appay fullname: Appay, Victor |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23817410$$D View this record in MEDLINE/PubMed https://hal.science/hal-02455351$$DView record in HAL |
| BookMark | eNp1kU9L5DAYxsPiso669z1JjnqovknTtD0O9c8MDHhx8RgyaaKRthmTVPBz7X4OP5MpM85BEMIbCL_n4cn7HKGDwQ0aoT8ELhiw-vLZ9v04uO6CUKA1gx9oRooCMs6BH6AZAKUZKXl5iI5CeAYADpT9Qoc0r0jJCMzQw5U1Rns9RCs7vOw3UkXsDJ4_aiyHFjdv0fX6UXbu1fox4OVgtIrWDTid-KTx-7_3__geN7rrcOOS3sc-uZ2gn0Z2Qf_e3cfo7831fbPIVne3y2a-yhQpK8hYvTZVSQzPYa1MW1NKNZkGcF6wkpuW5kxXlW4hxSyYKlkBXKWxBkpUnR-j863vk-zExtte-jfhpBWL-UpMb-nDRZEX5JUk9mzLbrx7GXWIordBpeBy0G4MgjBCUhBWT7anO3Rc97rdO38uLgGwBZR3IXht9ggBMXUjPrsRu26ShH-RKBvltMvope2-F34AeO-VAg |
| CitedBy_id | crossref_primary_10_1128_JVI_02245_16 crossref_primary_10_1016_j_ebiom_2018_11_053 crossref_primary_10_1371_journal_ppat_1004702 crossref_primary_10_1002_jmv_24784 crossref_primary_10_1155_2017_4234765 crossref_primary_10_1371_journal_pone_0097755 crossref_primary_10_1007_s00430_019_00608_7 crossref_primary_10_1038_ncomms14760 crossref_primary_10_1016_j_coi_2014_05_003 crossref_primary_10_3390_ijms22189973 crossref_primary_10_2147_RMHP_S257907 crossref_primary_10_3390_cells9030729 crossref_primary_10_1002_eji_201546178 crossref_primary_10_1007_s11357_017_9982_x crossref_primary_10_1007_s00262_014_1596_x crossref_primary_10_1016_j_smim_2023_101816 crossref_primary_10_3389_fimmu_2018_00648 crossref_primary_10_1097_BS9_0000000000000213 crossref_primary_10_1093_cei_uxad132 crossref_primary_10_1111_acel_12311 crossref_primary_10_1007_s12016_013_8391_x crossref_primary_10_1371_journal_pone_0181161 crossref_primary_10_4049_jimmunol_1801475 crossref_primary_10_3389_fimmu_2017_01189 crossref_primary_10_4049_jimmunol_1602019 crossref_primary_10_1111_cei_12297 crossref_primary_10_1186_s12979_015_0052_x crossref_primary_10_3389_fimmu_2021_666983 crossref_primary_10_1189_jlb_5A1213_650RR crossref_primary_10_1002_cyto_a_22470 crossref_primary_10_3389_fimmu_2015_00003 crossref_primary_10_1111_imr_12922 crossref_primary_10_1016_j_clim_2017_04_008 crossref_primary_10_1002_cti2_1072 crossref_primary_10_1016_j_crmeth_2023_100619 crossref_primary_10_18632_oncotarget_10096 crossref_primary_10_3389_fimmu_2017_00982 crossref_primary_10_1038_s41598_017_05849_1 crossref_primary_10_3389_fimmu_2017_00105 crossref_primary_10_1002_eji_201570044 crossref_primary_10_1016_j_arr_2017_10_005 crossref_primary_10_1016_j_exger_2014_03_020 crossref_primary_10_1002_cyto_a_22740 crossref_primary_10_1186_s12879_024_09158_7 crossref_primary_10_1093_infdis_jiaa400 crossref_primary_10_3389_fimmu_2024_1397483 crossref_primary_10_3390_cells10020373 crossref_primary_10_3389_fimmu_2018_00389 crossref_primary_10_3390_v13122372 crossref_primary_10_3389_fimmu_2018_00940 crossref_primary_10_3390_ijms21238903 |
| Cites_doi | 10.1038/nri1030 10.1086/644509 10.1016/j.mad.2006.01.011 10.1084/jem.20050882 10.1111/j.1365-2249.2006.03038.x 10.1038/nri2781 10.1038/nm0402-379 10.1084/jem.171.5.1597 10.1111/j.1600-065X.2006.00468.x 10.1086/314568 10.1084/jem.20090348 10.1016/j.it.2011.11.005 10.1172/JCI39269 10.1189/jlb.72.1.65 10.1002/cyto.a.20643 10.1007/s12185-011-0907-7 10.1172/JCI5409 10.1016/j.jaci.2008.03.033 10.1038/nri2318 10.4049/jimmunol.170.4.2022 10.1038/ni1436 10.1182/blood-2008-01-136713 10.1002/eji.200525983 10.1086/322843 10.1038/ni.2394 10.1146/annurev.cellbio.23.090506.123547 10.1016/j.micinf.2004.12.009 10.1182/blood-2010-01-255166 10.1084/jem.20030235 10.1038/nri2471 10.4049/jimmunol.172.3.1637 |
| ContentType | Journal Article |
| Copyright | Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: Distributed under a Creative Commons Attribution 4.0 International License |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 1XC |
| DOI | 10.4049/jimmunol.1202940 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Hyper Article en Ligne (HAL) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1550-6606 |
| EndPage | 1306 |
| ExternalDocumentID | oai_HAL_hal_02455351v1 23817410 10_4049_jimmunol_1202940 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -~X .55 0R~ 18M 1KJ 2WC 34G 39C 53G 5GY 5RE 5VS 5WD 79B 85S AARDX AAYXX ABCQX ABDFA ABEJV ABGNP ABJNI ABOCM ABPPZ ABXVV ACGFO ACGFS ACIWK ACNCT ACPRK ADBBV ADIPN ADNWM AENEX AETEA AFHIN AFOSN AFRAH AGORE AHMMS AHWXS AIZAD ALMA_UNASSIGNED_HOLDINGS ARBBW BAWUL BCRHZ BTFSW CITATION D0L DIK DU5 E3Z EBS EJD F5P FRP GX1 IH2 K-O KQ8 L7B OCZFY OK1 OWPYF P0W P2P PQQKQ R.V RHI ROX RZQ SJN TR2 TWZ W8F WH7 WOQ X7M XJT XSW XTH YHG CGR CUY CVF ECM EIF NPM 7X8 1XC UMC |
| ID | FETCH-LOGICAL-c1780-49bf871f630bcfd9222e1222e0665476fd234e88ed0ffe54c74506c450b021c93 |
| ISSN | 0022-1767 1550-6606 |
| IngestDate | Fri May 09 12:14:29 EDT 2025 Mon Jul 21 10:17:42 EDT 2025 Thu Apr 03 07:03:23 EDT 2025 Tue Jul 01 05:19:50 EDT 2025 Thu Apr 24 23:08:34 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | https://academic.oup.com/pages/standard-publication-reuse-rights Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c1780-49bf871f630bcfd9222e1222e0665476fd234e88ed0ffe54c74506c450b021c93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-2097-9677 0000-0002-1691-4531 0000-0003-4596-7373 |
| PMID | 23817410 |
| PQID | 1411630499 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | hal_primary_oai_HAL_hal_02455351v1 proquest_miscellaneous_1411630499 pubmed_primary_23817410 crossref_primary_10_4049_jimmunol_1202940 crossref_citationtrail_10_4049_jimmunol_1202940 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-Aug-01 |
| PublicationDateYYYYMMDD | 2013-08-01 |
| PublicationDate_xml | – month: 08 year: 2013 text: 2013-Aug-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | The Journal of immunology (1950) |
| PublicationTitleAlternate | J Immunol |
| PublicationYear | 2013 |
| Publisher | Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists |
| Publisher_xml | – name: Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists |
| References | Karrer (2025032405114774200_r21) 2003; 170 Willcox (2025032405114774200_r18) 2012; 13 Pitard (2025032405114774200_r15) 2008; 112 Vermijlen (2025032405114774200_r17) 2010; 207 Hayday (2025032405114774200_r28) 2007; 8 Sylwester (2025032405114774200_r5) 2005; 202 Argentati (2025032405114774200_r10) 2002; 72 Lafarge (2025032405114774200_r14) 2001; 184 Dorshkind (2025032405114774200_r1) 2009; 9 Appay (2025032405114774200_r19) 2002; 8 O’Hara (2025032405114774200_r26) 2012; 33 Knight (2025032405114774200_r16) 2010; 116 Déchanet (2025032405114774200_r13) 1999; 103 Poccia (2025032405114774200_r7) 2005; 7 Kanaya (2025032405114774200_r32) 2006; 144 Giorgi (2025032405114774200_r20) 1993; 6 Musiani (2025032405114774200_r30) 1990; 7 Parker (2025032405114774200_r33) 1990; 171 Hayday (2025032405114774200_r9) 2003; 3 Koch (2025032405114774200_r3) 2006; 127 Michishita (2025032405114774200_r11) 2011; 94 Déchanet (2025032405114774200_r12) 1999; 179 Couzi (2025032405114774200_r25) 2009; 200 Ciofani (2025032405114774200_r29) 2007; 23 Caccamo (2025032405114774200_r24) 2005; 35 Appay (2025032405114774200_r4) 2008; 73 De Rosa (2025032405114774200_r23) 2004; 172 Bonneville (2025032405114774200_r8) 2010; 10 Dieli (2025032405114774200_r22) 2003; 198 McLean-Tooke (2025032405114774200_r31) 2008; 122 Sauce (2025032405114774200_r6) 2009; 119 Thedrez (2025032405114774200_r27) 2007; 215 Nikolich-Zugich (2025032405114774200_r2) 2008; 8 |
| References_xml | – volume: 3 start-page: 233 year: 2003 ident: 2025032405114774200_r9 article-title: Immunoregulation in the tissues by γδ T cells publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1030 – volume: 200 start-page: 1415 year: 2009 ident: 2025032405114774200_r25 article-title: Common features of gammadelta T cells and CD8+ αβ T cells responding to human cytomegalovirus infection in kidney transplant recipients publication-title: J. Infect. Dis. doi: 10.1086/644509 – volume: 127 start-page: 538 year: 2006 ident: 2025032405114774200_r3 article-title: Human cytomegalovirus infection and T cell immunosenescence: a mini review publication-title: Mech. Ageing Dev. doi: 10.1016/j.mad.2006.01.011 – volume: 202 start-page: 673 year: 2005 ident: 2025032405114774200_r5 article-title: Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects publication-title: J. Exp. Med. doi: 10.1084/jem.20050882 – volume: 144 start-page: 85 year: 2006 ident: 2025032405114774200_r32 article-title: Maturational alterations of peripheral T cell subsets and cytokine gene expression in 22q11.2 deletion syndrome publication-title: Clin. Exp. Immunol. doi: 10.1111/j.1365-2249.2006.03038.x – volume: 10 start-page: 467 year: 2010 ident: 2025032405114774200_r8 article-title: γδ T cell effector functions: a blend of innate programming and acquired plasticity publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2781 – volume: 8 start-page: 379 year: 2002 ident: 2025032405114774200_r19 article-title: Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections publication-title: Nat. Med. doi: 10.1038/nm0402-379 – volume: 171 start-page: 1597 year: 1990 ident: 2025032405114774200_r33 article-title: Evidence for extrathymic changes in the T cell receptor γ/δ repertoire publication-title: J. Exp. Med. doi: 10.1084/jem.171.5.1597 – volume: 215 start-page: 123 year: 2007 ident: 2025032405114774200_r27 article-title: Self/non-self discrimination by human γδ T cells: simple solutions for a complex issue? publication-title: Immunol. Rev. doi: 10.1111/j.1600-065X.2006.00468.x – volume: 179 start-page: 1 year: 1999 ident: 2025032405114774200_r12 article-title: Major expansion of γδ T lymphocytes following cytomegalovirus infection in kidney allograft recipients publication-title: J. Infect. Dis. doi: 10.1086/314568 – volume: 207 start-page: 807 year: 2010 ident: 2025032405114774200_r17 article-title: Human cytomegalovirus elicits fetal γδ T cell responses in utero publication-title: J. Exp. Med. doi: 10.1084/jem.20090348 – volume: 33 start-page: 84 year: 2012 ident: 2025032405114774200_r26 article-title: Memory T cell inflation: understanding cause and effect publication-title: Trends Immunol. doi: 10.1016/j.it.2011.11.005 – volume: 119 start-page: 3070 year: 2009 ident: 2025032405114774200_r6 article-title: Evidence of premature immune aging in patients thymectomized during early childhood publication-title: J. Clin. Invest. doi: 10.1172/JCI39269 – volume: 72 start-page: 65 year: 2002 ident: 2025032405114774200_r10 article-title: Numerical and functional alterations of circulating γδ T lymphocytes in aged people and centenarians publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.72.1.65 – volume: 73 start-page: 975 year: 2008 ident: 2025032405114774200_r4 article-title: Phenotype and function of human T lymphocyte subsets: consensus and issues publication-title: Cytometry A doi: 10.1002/cyto.a.20643 – volume: 94 start-page: 230 year: 2011 ident: 2025032405114774200_r11 article-title: Age-associated alteration of γδ T-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cells publication-title: Int. J. Hematol. doi: 10.1007/s12185-011-0907-7 – volume: 103 start-page: 1437 year: 1999 ident: 2025032405114774200_r13 article-title: Implication of γδ T cells in the human immune response to cytomegalovirus publication-title: J. Clin. Invest. doi: 10.1172/JCI5409 – volume: 122 start-page: 362 year: 2008 ident: 2025032405114774200_r31 article-title: Immunologic defects in 22q11.2 deletion syndrome publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2008.03.033 – volume: 8 start-page: 512 year: 2008 ident: 2025032405114774200_r2 article-title: Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2318 – volume: 170 start-page: 2022 year: 2003 ident: 2025032405114774200_r21 article-title: Memory inflation: continuous accumulation of antiviral CD8+ T cells over time publication-title: J. Immunol. doi: 10.4049/jimmunol.170.4.2022 – volume: 8 start-page: 137 year: 2007 ident: 2025032405114774200_r28 article-title: Key factors in the organized chaos of early T cell development publication-title: Nat. Immunol. doi: 10.1038/ni1436 – volume: 112 start-page: 1317 year: 2008 ident: 2025032405114774200_r15 article-title: Long-term expansion of effector/memory Vδ2-γδ T cells is a specific blood signature of CMV infection publication-title: Blood doi: 10.1182/blood-2008-01-136713 – volume: 6 start-page: 904 year: 1993 ident: 2025032405114774200_r20 article-title: Elevated levels of CD38+CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up: the Los Angeles Center, Multicenter AIDS Cohort Study publication-title: J. Acquir. Immune Defic. Syndr. – volume: 35 start-page: 1764 year: 2005 ident: 2025032405114774200_r24 article-title: Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vγ9Vδ2 naive, memory and effector T cell subsets publication-title: Eur. J. Immunol. doi: 10.1002/eji.200525983 – volume: 184 start-page: 533 year: 2001 ident: 2025032405114774200_r14 article-title: Cytomegalovirus infection in transplant recipients resolves when circulating γδ T lymphocytes expand, suggesting a protective antiviral role publication-title: J. Infect. Dis. doi: 10.1086/322843 – volume: 13 start-page: 872 year: 2012 ident: 2025032405114774200_r18 article-title: Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor publication-title: Nat. Immunol. doi: 10.1038/ni.2394 – volume: 23 start-page: 463 year: 2007 ident: 2025032405114774200_r29 article-title: The thymus as an inductive site for T lymphopoiesis publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.23.090506.123547 – volume: 7 start-page: 518 year: 2005 ident: 2025032405114774200_r7 article-title: Antiviral reactivities of γδ T cells publication-title: Microbes Infect. doi: 10.1016/j.micinf.2004.12.009 – volume: 116 start-page: 2164 year: 2010 ident: 2025032405114774200_r16 article-title: The role of Vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation publication-title: Blood doi: 10.1182/blood-2010-01-255166 – volume: 198 start-page: 391 year: 2003 ident: 2025032405114774200_r22 article-title: Differentiation of effector/memory Vδ2 T cells and migratory routes in lymph nodes or inflammatory sites publication-title: J. Exp. Med. doi: 10.1084/jem.20030235 – volume: 9 start-page: 57 year: 2009 ident: 2025032405114774200_r1 article-title: The ageing immune system: is it ever too old to become young again? publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2471 – volume: 172 start-page: 1637 year: 2004 ident: 2025032405114774200_r23 article-title: Ontogeny of γδ T cells in humans publication-title: J. Immunol. doi: 10.4049/jimmunol.172.3.1637 – volume: 7 start-page: 219 year: 1990 ident: 2025032405114774200_r30 article-title: Intrathymic deficient expansion of T cell precursors in Down syndrome publication-title: Am. J. Med. Genet. Suppl. |
| SSID | ssj0006024 |
| Score | 2.0780265 |
| Snippet | γδ T cells represent a subset of unconventional T lymphocytes that are known for their reactivity against different pathogens and considered as intermediate... |
| SourceID | hal proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1300 |
| SubjectTerms | Adult Age Factors Aged Aged, 80 and over Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Cytotoxicity, Immunologic - immunology Humans Immunology Life Sciences Lymphocyte Activation - immunology Lymphocyte Count Middle Aged Receptors, Antigen, T-Cell, gamma-delta - immunology T-Lymphocyte Subsets - immunology Thymus Gland - immunology |
| Title | Differential Impact of Age and Cytomegalovirus Infection on the γδ T Cell Compartment |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23817410 https://www.proquest.com/docview/1411630499 https://hal.science/hal-02455351 |
| Volume | 191 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6lRaBeEBRow0sLIgcUJV177bX3GEJphBoOkIrcIj_WEBRslNgV5Udxgd_R38SMd-24UYsoUrSKHXvk7Hyex87sDCEvZBx4MVeyFzDBeg4XUU8m8F7xRIYh507CJG5OHr8ToxPn7dSdtlo_G1lLRR72ox-X7iv5H67COeAr7pK9BmdronACvgN_YQQOw_hPPH5tupvkZcWMer_j4JOOCQzP8uyrAhWQnc6XxQpkgU68Sk2EoNsZHnZe8XJ0upPuENfxSgGxzOuEmC9rODWM1zluK9HlmzplkIw1lhTeZ8V3U5gga4Ttx7jeXwq5o_mqDND7i_rHY3CwtQTUhQ1qXAUAwzQAWbMoEfchW-hbDV2zYIHNI_xqwWK9gcDydBeOvjJy1wUvVjBxQTBLq4FA3hCzGINrqGw4FJepAwfcH1QHZk76ls1s6bC16qvC_Rsasc5TBA8JacwqCjNDYYvcsMEtQUVwNF2nFAlmO1V1evyDOiyOFA42n-GCGbT1GZNwr_JwSktncofcNlymA423u6Sl0l1yUzctPdslt8YmHeMe-dgEINUApFlCAYAUAEg3AEhrAFL4AADp-a_z33RCEXi0Abz75OTN4WQ46plOHb3I8nx4x2WYgOedCM7CKIklGJ3KwkE3txZJbHNH-b6KGTyW60Se4zIRwRCCjRlJ_oBsp1mq9gn1vMgNBBi2gQvz5sqQuTCfoQoCz4_Anm6Tg2riZpEpY4_dVIA3VzCrTV7Wd3zTJVz-cu1z4EV9GdZeHw2OZ3gOcxRc7lqnVps8q1g1A2GMEbYgVVmxAj_aAv8GVxHaZE_zsKaFtjGY7-zhNR7nEdlZv0GPyXa-LNQTMILz8GmJvD_7G656 |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Differential+Impact+of+Age+and+Cytomegalovirus+Infection+on+the+%CE%B3%CE%B4+T+Cell+Compartment&rft.jtitle=The+Journal+of+immunology+%281950%29&rft.au=Roux%2C+Antoine&rft.au=Mourin%2C+Gis%C3%A8le&rft.au=Larsen%2C+Martin&rft.au=Fastenackels%2C+Sol%C3%A8ne&rft.date=2013-08-01&rft.issn=0022-1767&rft.eissn=1550-6606&rft.volume=191&rft.issue=3&rft.spage=1300&rft.epage=1306&rft_id=info:doi/10.4049%2Fjimmunol.1202940&rft.externalDBID=n%2Fa&rft.externalDocID=10_4049_jimmunol_1202940 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1767&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1767&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1767&client=summon |