Mulberry leaves supplementation alters lipid metabolism and promotes fatty acid β oxidation in growing mutton sheep
Mulberry leaves are an unconventional feed with fiber and various active ingredients, and acknowledged likely to regulate lipid metabolism, while the molecular mechanism remains undefined. Therefore, our objective was to define the role of mulberry leaves on the overall lipid metabolism. We conducte...
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| Published in | Journal of animal science Vol. 102 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
03.01.2024
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| Abstract | Mulberry leaves are an unconventional feed with fiber and various active ingredients, and acknowledged likely to regulate lipid metabolism, while the molecular mechanism remains undefined. Therefore, our objective was to define the role of mulberry leaves on the overall lipid metabolism. We conducted a feeding experiment of three groups on growing mutton sheep fed with dried mulberry leaves or with fermented mulberry leaves or without mulberry leaves (as control). Analyses of transcriptome and widely target lipids demonstrated the addition of mulberry leaves triggered big perturbations in genes and metabolites related to glycerolipid, phospholipid, ether lipid and sphingolipid metabolism. Additionally, the variations of above lipids in the treatment of mulberry leaves possibly facilitate immunity enhancement of growing mutton sheep via the activation of complement and coagulation cascades. Furthermore, treatments with mulberry leaves could expedite proceedings of lipid degradation and fatty acid β oxidation in mitochondria, thereby to achieve the effect of lipid reduction. Besides, added dried mulberry leaves also fuel fatty acid β-oxidation in peroxisomes and own much stronger lipolysis than added fermented mulberry leaves, possibly attributed to high fiber content in dried mulberry leaves. These findings establish the novel lipid-lowering role and immune protection of mulberry leaves, which lays the foundation for the medicinal application in mulberry leaves. |
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| AbstractList | Mulberry leaves (MLs) are an unconventional feed with fiber and various active ingredients, and are acknowledged as likely to regulate lipid metabolism, while the molecular mechanism remains undefined. Therefore, our objective was to define the role of MLs on the overall lipid metabolism. We conducted a feeding experiment of three groups on growing mutton sheep fed with dried mulberry leaves (DMLs), with fermented mulberry leaves (FMLs), or without MLs (as control). Analyses of transcriptome and widely target lipids demonstrated the addition of MLs triggered big perturbations in genes and metabolites related to glycerolipid, phospholipid, ether lipid, and sphingolipid metabolism. Additionally, the variations of the above lipids in the treatment of MLs possibly facilitate immunity enhancement of growing mutton sheep via the activation of complement and coagulation cascades. Furthermore, treatments with MLs could expedite proceedings of lipid degradation and fatty acid β oxidation in mitochondria, thereby to achieve the effect of lipid reduction. Besides, added DMLs also fuel fatty acid β-oxidation in peroxisomes and own much stronger lipolysis than added FMLs, possibly attributed to high fiber content in DMLs. These findings establish the novel lipid-lowering role and immune protection of MLs, which lays the foundation for the medicinal application of MLs.Mulberry leaves (MLs) are an unconventional feed with fiber and various active ingredients, and are acknowledged as likely to regulate lipid metabolism, while the molecular mechanism remains undefined. Therefore, our objective was to define the role of MLs on the overall lipid metabolism. We conducted a feeding experiment of three groups on growing mutton sheep fed with dried mulberry leaves (DMLs), with fermented mulberry leaves (FMLs), or without MLs (as control). Analyses of transcriptome and widely target lipids demonstrated the addition of MLs triggered big perturbations in genes and metabolites related to glycerolipid, phospholipid, ether lipid, and sphingolipid metabolism. Additionally, the variations of the above lipids in the treatment of MLs possibly facilitate immunity enhancement of growing mutton sheep via the activation of complement and coagulation cascades. Furthermore, treatments with MLs could expedite proceedings of lipid degradation and fatty acid β oxidation in mitochondria, thereby to achieve the effect of lipid reduction. Besides, added DMLs also fuel fatty acid β-oxidation in peroxisomes and own much stronger lipolysis than added FMLs, possibly attributed to high fiber content in DMLs. These findings establish the novel lipid-lowering role and immune protection of MLs, which lays the foundation for the medicinal application of MLs. Abstract Mulberry leaves (MLs) are an unconventional feed with fiber and various active ingredients, and are acknowledged as likely to regulate lipid metabolism, while the molecular mechanism remains undefined. Therefore, our objective was to define the role of MLs on the overall lipid metabolism. We conducted a feeding experiment of three groups on growing mutton sheep fed with dried mulberry leaves (DMLs), with fermented mulberry leaves (FMLs), or without MLs (as control). Analyses of transcriptome and widely target lipids demonstrated the addition of MLs triggered big perturbations in genes and metabolites related to glycerolipid, phospholipid, ether lipid, and sphingolipid metabolism. Additionally, the variations of the above lipids in the treatment of MLs possibly facilitate immunity enhancement of growing mutton sheep via the activation of complement and coagulation cascades. Furthermore, treatments with MLs could expedite proceedings of lipid degradation and fatty acid β oxidation in mitochondria, thereby to achieve the effect of lipid reduction. Besides, added DMLs also fuel fatty acid β-oxidation in peroxisomes and own much stronger lipolysis than added FMLs, possibly attributed to high fiber content in DMLs. These findings establish the novel lipid-lowering role and immune protection of MLs, which lays the foundation for the medicinal application of MLs. Mulberry leaves are an unconventional feed with fiber and various active ingredients, and acknowledged likely to regulate lipid metabolism, while the molecular mechanism remains undefined. Therefore, our objective was to define the role of mulberry leaves on the overall lipid metabolism. We conducted a feeding experiment of three groups on growing mutton sheep fed with dried mulberry leaves or with fermented mulberry leaves or without mulberry leaves (as control). Analyses of transcriptome and widely target lipids demonstrated the addition of mulberry leaves triggered big perturbations in genes and metabolites related to glycerolipid, phospholipid, ether lipid and sphingolipid metabolism. Additionally, the variations of above lipids in the treatment of mulberry leaves possibly facilitate immunity enhancement of growing mutton sheep via the activation of complement and coagulation cascades. Furthermore, treatments with mulberry leaves could expedite proceedings of lipid degradation and fatty acid β oxidation in mitochondria, thereby to achieve the effect of lipid reduction. Besides, added dried mulberry leaves also fuel fatty acid β-oxidation in peroxisomes and own much stronger lipolysis than added fermented mulberry leaves, possibly attributed to high fiber content in dried mulberry leaves. These findings establish the novel lipid-lowering role and immune protection of mulberry leaves, which lays the foundation for the medicinal application in mulberry leaves. |
| Author | Jiao, Feng Zhang, Minjuan Wang, Hexin Cui, Xiaopeng Su, Chao Yang, Yuxin Qian, Wei Liu, Shuang Bao, Lijun Wei, Xinlan Shi, Xiang Qian, Yonghua |
| Author_xml | – sequence: 1 givenname: Xiaopeng orcidid: 0000-0001-7238-7759 surname: Cui fullname: Cui, Xiaopeng organization: College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212000, China – sequence: 2 givenname: Yuxin orcidid: 0000-0002-1742-2328 surname: Yang fullname: Yang, Yuxin organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 3 givenname: Minjuan surname: Zhang fullname: Zhang, Minjuan organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 4 givenname: Lijun surname: Bao fullname: Bao, Lijun organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 5 givenname: Feng surname: Jiao fullname: Jiao, Feng organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 6 givenname: Shuang surname: Liu fullname: Liu, Shuang organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 7 givenname: Hexin surname: Wang fullname: Wang, Hexin organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 8 givenname: Xinlan surname: Wei fullname: Wei, Xinlan organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 9 givenname: Wei surname: Qian fullname: Qian, Wei organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 10 givenname: Xiang surname: Shi fullname: Shi, Xiang organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 11 givenname: Chao surname: Su fullname: Su, Chao organization: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China – sequence: 12 givenname: Yonghua surname: Qian fullname: Qian, Yonghua organization: Shenzhen Fengnong Holding Co., Ltd , Shenzhen, Guangdong 518000, China |
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| Cites_doi | 10.1021/acs.analchem.0c01870 10.1152/ajpendo.00054.2012 10.1016/j.molcel.2020.05.007 10.1096/fj.202100882R 10.1016/j.aninu.2020.08.005 10.1210/endocr/bqz046 10.1016/j.envpol.2020.116377 10.3390/nu11051017 10.1016/j.ijbiomac.2021.10.010 10.3390/cancers14030772 10.1074/jbc.M117.786574 10.1016/j.jcmgh.2020.10.006 10.1038/ni.1923 10.1093/bioinformatics/btp616 10.1038/s41467-021-27279-4 10.1038/nmeth.3317 10.1002/art.41624 10.1016/j.celrep.2021.108972 10.1016/j.healun.2021.05.020 10.1016/j.plipres.2020.101084 10.1186/s13046-017-0525-1 10.1136/gutjnl-2020-322509 10.1016/j.chroma.2005.08.016 10.1038/nbt.3122 10.1016/j.cmet.2021.06.006 10.1021/jf9025376 10.1161/CIRCULATIONAHA.120.047420 10.1038/s41467-017-02068-0 10.1016/j.atherosclerosis.2018.02.025 10.1016/j.cbi.2015.01.023 10.1016/j.cmet.2014.12.002 10.1073/pnas.1310894110 10.1093/bioinformatics/btp612 10.1016/j.freeradbiomed.2021.02.033 10.7150/thno.69826 10.1038/s41598-017-18393-9 10.1016/j.foodchem.2020.127856 10.1186/s13059-014-0550-8 10.1016/j.tem.2020.11.005 10.1016/j.jlr.2022.100225 10.1007/s13238-017-0423-5 10.1161/CIRCULATIONAHA.119.041882 10.3390/cancers13174391 10.3389/fnut.2021.758403 10.1016/j.jep.2020.113324 10.1096/fj.201500097R 10.1186/1471-2105-12-323 10.1016/j.jnutbio.2005.08.005 |
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| Keywords | Mulberry leaves fatty acid degradation growing mutton sheep fatty acid β oxidation lipid metabolism |
| Language | English |
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| References | Pertea (2024062509585138500_CIT0032) 2015; 33 Benjamin (2024062509585138500_CIT0002) 2013; 110 Velazquez-Villegas (2024062509585138500_CIT0043) 2018; 9 Wang (2024062509585138500_CIT0044) 2010; 26 He (2024062509585138500_CIT0013) 2020; 79 Park (2024062509585138500_CIT0031) 2006; 17 Bhuyan (2024062509585138500_CIT0003) 2021; 73 Li (2024062509585138500_CIT0023) 2022; 9 Du (2024062509585138500_CIT0008) 2017; 36 Li (2024062509585138500_CIT0020) 2011; 12 Ricklin (2024062509585138500_CIT0036) 2010; 11 Busnelli (2024062509585138500_CIT0005) 2018; 271 White (2024062509585138500_CIT0045) 2012; 303 Robinson (2024062509585138500_CIT0037) 2010; 26 Kim (2024062509585138500_CIT0017) 2015; 12 Li (2024062509585138500_CIT0022) 2021; 192 Love (2024062509585138500_CIT0026) 2014; 15 Hoffman (2024062509585138500_CIT0014) 2021; 143 Li (2024062509585138500_CIT0021) 2019; 11 Fischbeck (2024062509585138500_CIT0010) 2009; 57 Tabe (2024062509585138500_CIT0041) 2016; 30 Sun (2024062509585138500_CIT0039) 2021; 265 Ding (2024062509585138500_CIT0007) 2022; 12 Petrusca (2024062509585138500_CIT0033) 2022; 14 Wu (2024062509585138500_CIT0046) 2021; 32 Zhang (2024062509585138500_CIT0049) 2021; 11 Ribeiro (2024062509585138500_CIT0035) 2018; 8 Kono (2024062509585138500_CIT0019) 2022; 63 Xu (2024062509585138500_CIT0047) 2022; 9 Barron (2024062509585138500_CIT0001) 2021; 8 Dean (2024062509585138500_CIT0006) 2018; 9 Pacetti (2024062509585138500_CIT0030) 2005; 1097 Liu (2024062509585138500_CIT0024) 2021; 7 Ishihama (2024062509585138500_CIT0016) 2021; 35 Huang (2024062509585138500_CIT0015) 2020; 92 Green (2024062509585138500_CIT0011) 2021; 33 Zhou (2024062509585138500_CIT0050) 2021; 339 Tzou (2024062509585138500_CIT0042) 2021; 35 Boroda (2024062509585138500_CIT0004) 2017; 292 Recazens (2024062509585138500_CIT0034) 2021; 82 Mak (2024062509585138500_CIT0027) 2021; 12 Schlaepfer (2024062509585138500_CIT0038) 2020; 161 Koh (2024062509585138500_CIT0018) 2021; 70 Hadas (2024062509585138500_CIT0012) 2020; 141 Miao (2024062509585138500_CIT0028) 2015; 228 Sunami (2024062509585138500_CIT0040) 2021; 13 Yu (2024062509585138500_CIT0048) 2021; 271 Lodhi (2024062509585138500_CIT0025) 2015; 21 Oreschak (2024062509585138500_CIT0029) 2021; 40 Fan (2024062509585138500_CIT0009) 2021; 167 |
| References_xml | – volume: 92 start-page: 11250 year: 2020 ident: 2024062509585138500_CIT0015 article-title: Separation of glycolipids/sphingolipids from glycerophospholipids on TiO2 coating in aprotic solvent for rapid comprehensive lipidomic analysis with liquid microjunction surface sampling-mass spectrometry publication-title: Anal. Chem doi: 10.1021/acs.analchem.0c01870 contributor: fullname: Huang – volume: 303 start-page: E308 year: 2012 ident: 2024062509585138500_CIT0045 article-title: NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise publication-title: Am. J. Physiol. Endocrinol. Metab doi: 10.1152/ajpendo.00054.2012 contributor: fullname: White – volume: 79 start-page: 30 year: 2020 ident: 2024062509585138500_CIT0013 article-title: Acetyl-CoA derived from hepatic peroxisomal beta-oxidation inhibits autophagy and promotes steatosis via mTORC1 activation publication-title: Mol. Cell doi: 10.1016/j.molcel.2020.05.007 contributor: fullname: He – volume: 35 start-page: 1 year: 2021 ident: 2024062509585138500_CIT0016 article-title: LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia publication-title: FASEB J doi: 10.1096/fj.202100882R contributor: fullname: Ishihama – volume: 7 start-page: 421 year: 2021 ident: 2024062509585138500_CIT0024 article-title: Mulberry leaf powder regulates antioxidative capacity and lipid metabolism in finishing pigs publication-title: Anim. Nutr doi: 10.1016/j.aninu.2020.08.005 contributor: fullname: Liu – volume: 161 start-page: 1 year: 2020 ident: 2024062509585138500_CIT0038 article-title: CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential publication-title: Endocrinology doi: 10.1210/endocr/bqz046 contributor: fullname: Schlaepfer – volume: 271 start-page: 116377 year: 2021 ident: 2024062509585138500_CIT0048 article-title: Uranium inhibits mammalian mitochondrial cytochrome c oxidase and ATP synthase publication-title: Environ. Pollut doi: 10.1016/j.envpol.2020.116377 contributor: fullname: Yu – volume: 11 start-page: 1017 year: 2019 ident: 2024062509585138500_CIT0021 article-title: Mulberry leaf polyphenols and fiber induce synergistic antiobesity and display a modulation effect on gut microbiota and metabolites publication-title: Nutrients doi: 10.3390/nu11051017 contributor: fullname: Li – volume: 192 start-page: 452 year: 2021 ident: 2024062509585138500_CIT0022 article-title: Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice publication-title: Int. J. Biol. Macromol doi: 10.1016/j.ijbiomac.2021.10.010 contributor: fullname: Li – volume: 14 start-page: 772 year: 2022 ident: 2024062509585138500_CIT0033 article-title: GFI1-dependent repression of SGPP1 increases multiple myeloma cell survival publication-title: Cancers (Basel) doi: 10.3390/cancers14030772 contributor: fullname: Petrusca – volume: 292 start-page: 20481 year: 2017 ident: 2024062509585138500_CIT0004 article-title: The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3 publication-title: J. Biol. Chem doi: 10.1074/jbc.M117.786574 contributor: fullname: Boroda – volume: 11 start-page: 697 year: 2021 ident: 2024062509585138500_CIT0049 article-title: S100A11 promotes liver steatosis via FOXO1-mediated autophagy and lipogenesis publication-title: Cell Mol. Gastroenterol. Hepatol doi: 10.1016/j.jcmgh.2020.10.006 contributor: fullname: Zhang – volume: 11 start-page: 785 year: 2010 ident: 2024062509585138500_CIT0036 article-title: Complement: a key system for immune surveillance and homeostasis publication-title: Nat. Immunol doi: 10.1038/ni.1923 contributor: fullname: Ricklin – volume: 26 start-page: 139 year: 2010 ident: 2024062509585138500_CIT0037 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: Robinson – volume: 12 start-page: 1 year: 2021 ident: 2024062509585138500_CIT0027 article-title: AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway publication-title: Nat. Commun doi: 10.1038/s41467-021-27279-4 contributor: fullname: Mak – volume: 12 start-page: 357 year: 2015 ident: 2024062509585138500_CIT0017 article-title: HISAT: a fast spliced aligner with low memory requirements publication-title: Nat. Methods doi: 10.1038/nmeth.3317 contributor: fullname: Kim – volume: 73 start-page: 1021 year: 2021 ident: 2024062509585138500_CIT0003 article-title: Novel publication-title: Arthritis Rheumatol doi: 10.1002/art.41624 contributor: fullname: Bhuyan – volume: 35 start-page: 108972 year: 2021 ident: 2024062509585138500_CIT0042 article-title: Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress publication-title: Cell Rep doi: 10.1016/j.celrep.2021.108972 contributor: fullname: Tzou – volume: 40 start-page: 917 year: 2021 ident: 2024062509585138500_CIT0029 article-title: Variants in mycophenolate and CMV antiviral drug pharmacokinetic and pharmacodynamic genes and leukopenia in heart transplant recipients publication-title: J. Heart Lung. Transplant doi: 10.1016/j.healun.2021.05.020 contributor: fullname: Oreschak – volume: 82 start-page: 101084 year: 2021 ident: 2024062509585138500_CIT0034 article-title: Hormone-sensitive lipase: sixty years later publication-title: Prog. Lipid Res doi: 10.1016/j.plipres.2020.101084 contributor: fullname: Recazens – volume: 36 start-page: 1 year: 2017 ident: 2024062509585138500_CIT0008 article-title: Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma publication-title: J. Exp. Clin. Cancer Res doi: 10.1186/s13046-017-0525-1 contributor: fullname: Du – volume: 70 start-page: 1954 year: 2021 ident: 2024062509585138500_CIT0018 article-title: Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis publication-title: Gut doi: 10.1136/gutjnl-2020-322509 contributor: fullname: Koh – volume: 1097 start-page: 66 year: 2005 ident: 2024062509585138500_CIT0030 article-title: High performance liquid chromatography-tandem mass spectrometry of phospholipid molecular species in eggs from hens fed diets enriched in seal blubber oil publication-title: J. Chromatogr. A doi: 10.1016/j.chroma.2005.08.016 contributor: fullname: Pacetti – volume: 33 start-page: 290 year: 2015 ident: 2024062509585138500_CIT0032 article-title: StringTie enables improved reconstruction of a transcriptome from RNA-seq reads publication-title: Nat. Biotechnol doi: 10.1038/nbt.3122 contributor: fullname: Pertea – volume: 33 start-page: 1293 year: 2021 ident: 2024062509585138500_CIT0011 article-title: Sphingolipids in metabolic disease: the good, the bad, and the unknown publication-title: Cell Metab doi: 10.1016/j.cmet.2021.06.006 contributor: fullname: Green – volume: 57 start-page: 9469 year: 2009 ident: 2024062509585138500_CIT0010 article-title: Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS) publication-title: J. Agric. Food Chem doi: 10.1021/jf9025376 contributor: fullname: Fischbeck – volume: 143 start-page: 1139 year: 2021 ident: 2024062509585138500_CIT0014 article-title: Cardiomyocyte kruppel-like factor 5 promotes de novo ceramide biosynthesis and contributes to eccentric remodeling in ischemic cardiomyopathy publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.047420 contributor: fullname: Hoffman – volume: 9 start-page: 1 year: 2018 ident: 2024062509585138500_CIT0043 article-title: TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue publication-title: Nat. Commun doi: 10.1038/s41467-017-02068-0 contributor: fullname: Velazquez-Villegas – volume: 271 start-page: 156 year: 2018 ident: 2024062509585138500_CIT0005 article-title: Lipid phosphate phosphatase 3 in vascular pathophysiology publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2018.02.025 contributor: fullname: Busnelli – volume: 228 start-page: 79 year: 2015 ident: 2024062509585138500_CIT0028 article-title: Plasma lipidomics reveal profound perturbation of glycerophospholipids, fatty acids, and sphingolipids in diet-induced hyperlipidemia publication-title: Chem. Biol. Interact doi: 10.1016/j.cbi.2015.01.023 contributor: fullname: Miao – volume: 21 start-page: 51 year: 2015 ident: 2024062509585138500_CIT0025 article-title: Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability publication-title: Cell Metab doi: 10.1016/j.cmet.2014.12.002 contributor: fullname: Lodhi – volume: 110 start-page: 14912 year: 2013 ident: 2024062509585138500_CIT0002 article-title: Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity publication-title: Proc. Natl. Acad. Sci. U. S. A doi: 10.1073/pnas.1310894110 contributor: fullname: Benjamin – volume: 26 start-page: 136 year: 2010 ident: 2024062509585138500_CIT0044 article-title: DEGseq: an R package for identifying differentially expressed genes from RNA-seq data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp612 contributor: fullname: Wang – volume: 167 start-page: 1 year: 2021 ident: 2024062509585138500_CIT0009 article-title: NEAT1/hsa-miR-372-3p axis participates in rapamycin-induced lipid metabolic disorder publication-title: Free Radic. Biol. Med doi: 10.1016/j.freeradbiomed.2021.02.033 contributor: fullname: Fan – volume: 12 start-page: 3237 year: 2022 ident: 2024062509585138500_CIT0007 article-title: AGK regulates the progression to NASH by affecting mitochondria complex I function publication-title: Theranostics doi: 10.7150/thno.69826 contributor: fullname: Ding – volume: 8 start-page: 1 year: 2018 ident: 2024062509585138500_CIT0035 article-title: Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase publication-title: Sci. Rep doi: 10.1038/s41598-017-18393-9 contributor: fullname: Ribeiro – volume: 339 start-page: 127856 year: 2021 ident: 2024062509585138500_CIT0050 article-title: Determination and comparison of phospholipid profiles in eggs from seven different species using UHPLC-ESI-Triple TOF-MS publication-title: Food Chem doi: 10.1016/j.foodchem.2020.127856 contributor: fullname: Zhou – volume: 9 start-page: 1 year: 2022 ident: 2024062509585138500_CIT0047 article-title: Screening of lipid metabolism-related gene diagnostic signature for patients with dilated cardiomyopathy publication-title: Front. Cardiovasc. Med contributor: fullname: Xu – volume: 9 start-page: 1 year: 2022 ident: 2024062509585138500_CIT0023 article-title: Mulberry leaf polyphenols alleviated high-fat diet-induced obesity in mice publication-title: Front. Nutr contributor: fullname: Li – volume: 15 start-page: 1 year: 2014 ident: 2024062509585138500_CIT0026 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 contributor: fullname: Love – volume: 32 start-page: 48 year: 2021 ident: 2024062509585138500_CIT0046 article-title: Lipoprotein lipase and its regulators: an unfolding story publication-title: Trends Endocrinol. Metab doi: 10.1016/j.tem.2020.11.005 contributor: fullname: Wu – volume: 63 start-page: 100225 year: 2022 ident: 2024062509585138500_CIT0019 article-title: Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling publication-title: J. Lipid Res doi: 10.1016/j.jlr.2022.100225 contributor: fullname: Kono – volume: 9 start-page: 196 year: 2018 ident: 2024062509585138500_CIT0006 article-title: Structural and functional roles of ether lipids publication-title: Protein Cell doi: 10.1007/s13238-017-0423-5 contributor: fullname: Dean – volume: 141 start-page: 916 year: 2020 ident: 2024062509585138500_CIT0012 article-title: Altering sphingolipid metabolism attenuates cell death and inflammatory response after myocardial infarction publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.119.041882 contributor: fullname: Hadas – volume: 13 start-page: 4391 year: 2021 ident: 2024062509585138500_CIT0040 article-title: Lipid droplet-associated factors, PNPLA3, TM6SF2, and HSD17B proteins in hepatopancreatobiliary cancer publication-title: Cancers (Basel) doi: 10.3390/cancers13174391 contributor: fullname: Sunami – volume: 8 start-page: 1 year: 2021 ident: 2024062509585138500_CIT0001 article-title: Dietary folic acid alters metabolism of multiple vitamins in a CerS6- and sex-dependent manner publication-title: Front. Nutr doi: 10.3389/fnut.2021.758403 contributor: fullname: Barron – volume: 265 start-page: 1 year: 2021 ident: 2024062509585138500_CIT0039 article-title: Fufang Xueshuantong alleviates diabetic retinopathy by activating the PPAR signalling pathway and complement and coagulation cascades publication-title: J. Ethnopharmacol doi: 10.1016/j.jep.2020.113324 contributor: fullname: Sun – volume: 30 start-page: 2591 year: 2016 ident: 2024062509585138500_CIT0041 article-title: Lysophosphatidylethanolamine acyltransferase 1/membrane-bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons publication-title: FASEB J doi: 10.1096/fj.201500097R contributor: fullname: Tabe – volume: 12 start-page: 1 year: 2011 ident: 2024062509585138500_CIT0020 article-title: RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome publication-title: BMC Bioinf doi: 10.1186/1471-2105-12-323 contributor: fullname: Li – volume: 17 start-page: 337 year: 2006 ident: 2024062509585138500_CIT0031 article-title: Dietary gangliosides increase the content and molecular percentage of ether phospholipids containing 20:4n-6 and 22:6n-3 in weanling rat intestine publication-title: J. Nutr. Biochem doi: 10.1016/j.jnutbio.2005.08.005 contributor: fullname: Park |
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