Control of estrus and level of serum progesterone in swine by oral administration of altrenogest
A study was conducted to evaluate the efficacy of Altrenogest (AT), a synthetic progesterone, for control of estrus in swine. Forty-four gilts and sows which had shown estrus at least once were randomly assigned to four different treatment groups with feeding of 2.5kg of feed per head per day, which...
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| Published in | Japanese Journal of Swine Science (Japan) Vol. 25; no. 3; pp. 133 - 141 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society of Swine Science
1988
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0913-882X 1881-655X |
| DOI | 10.5938/youton.25.133 |
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| Abstract | A study was conducted to evaluate the efficacy of Altrenogest (AT), a synthetic progesterone, for control of estrus in swine. Forty-four gilts and sows which had shown estrus at least once were randomly assigned to four different treatment groups with feeding of 2.5kg of feed per head per day, which contained 4 different levels of AT of 5, 10, 15 and 20mg, for 18 consecutive days. Gilts and sows were checked twice a day for signs of estrus after withdrawal of AT, and were bred either by artificial insemination with fresh semen or by natural service. Concentration of progesterone in serum was determined by enzyme-immunoassay. Blood samples were collected from 19 gilts and sows on days before, during and after AT administration. 1) Estrus was suppressed during treatment by AT administration in all the doses. Estrus after withdrawal of AT was effectively controlled in gilts and sows given 10mg, 15mg and 20mg of AT, whereas the feeding of 5mg of AT resulted in increased incidences of anestrus (10 and 15mg: P<0.05, 20mg: P<0.01). The interval of estrus tended to become longer as the dose was raised. The conception rate and litter size were 75.0%, 9.8±3.4 and 75.0%, 9.4±3.1 for gilts and sows fed 15mg and 20mg, respectively. 2) The concentrations of progesterone in serum were higher (15.1-53.6ng/ml) during the luteal phase, decreased by day 17 of the estrus cycle and remained on a low level (<1.3ng/ml) through the estrus in all of the treated groups. Progesterone levels in blood following regression of corpora lutea remained on a low level during treatment with AT. Mean serum progesterone concentrations remained low by day 6 to 7 after the withdrawal of AT, but increased from 10.0ng/ml to 15.8ng/ml on day 9 to 10 after the withdrawal of AT in all of the treated groups except the 5mg group. (10 and 20mg: P<0.001, 15 mg: P<0.05). However, serum progesterone concentrations in the 5mg group continued to gradually rise up from the day of AT withdrawal up to day 9 or 10 after the AT withdrawal. The results of the present study revealed that AT, when given in feeding in doses of 15 or 20mg/head/day for 18 consecutive days, effectively controlled the occurrences of estrus in swine without exerting any adverse effect upon their fertility. |
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| AbstractList | A study was conducted to evaluate the efficacy of Altrenogest (AT), a synthetic progesterone, for control of estrus in swine. Forty-four gilts and sows which had shown estrus at least once were randomly assigned to four different treatment groups with feeding of 2.5kg of feed per head per day, which contained 4 different levels of AT of 5, 10, 15 and 20mg, for 18 consecutive days. Gilts and sows were checked twice a day for signs of estrus after withdrawal of AT, and were bred either by artificial insemination with fresh semen or by natural service. Concentration of progesterone in serum was determined by enzyme-immunoassay. Blood samples were collected from 19 gilts and sows on days before, during and after AT administration. 1) Estrus was suppressed during treatment by AT administration in all the doses. Estrus after withdrawal of AT was effectively controlled in gilts and sows given 10mg, 15mg and 20mg of AT, whereas the feeding of 5mg of AT resulted in increased incidences of anestrus (10 and 15mg: P<0.05, 20mg: P<0.01). The interval of estrus tended to become longer as the dose was raised. The conception rate and litter size were 75.0%, 9.8±3.4 and 75.0%, 9.4±3.1 for gilts and sows fed 15mg and 20mg, respectively. 2) The concentrations of progesterone in serum were higher (15.1-53.6ng/ml) during the luteal phase, decreased by day 17 of the estrus cycle and remained on a low level (<1.3ng/ml) through the estrus in all of the treated groups. Progesterone levels in blood following regression of corpora lutea remained on a low level during treatment with AT. Mean serum progesterone concentrations remained low by day 6 to 7 after the withdrawal of AT, but increased from 10.0ng/ml to 15.8ng/ml on day 9 to 10 after the withdrawal of AT in all of the treated groups except the 5mg group. (10 and 20mg: P<0.001, 15 mg: P<0.05). However, serum progesterone concentrations in the 5mg group continued to gradually rise up from the day of AT withdrawal up to day 9 or 10 after the AT withdrawal. The results of the present study revealed that AT, when given in feeding in doses of 15 or 20mg/head/day for 18 consecutive days, effectively controlled the occurrences of estrus in swine without exerting any adverse effect upon their fertility. |
| Author | Narashima, T Masuda, H Itoh, Y. (Tokyo-to. Livestock Experiment Station, Ome (Japan)) Kondo, Y Yanaka, T |
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| References | 25) 菅原七郎・高木優二・正木淳二・佐藤正勝・川村利明・津志田農・大槻宗生・佐々間福雄・塩原広之・柏崎直己・杉本輝夫・武田光彦: 畜産の研究, 42, 261-264, 1988. 30) REDMER, D. A. and B. N. DAY: J. Anim. Sci., 53, 1088-1094, 1981. 6) POLGE, C.: Vet. Rec., 77, 232-236, 1965. 11) WEBEL, S. K.: J. Anim. Sci., 42 (Abstr.), 1358, 1976. 21) STEVENSON, J. S., D. L. DAVIS and D. S. POLLMANN: J. Anim. Sci., 61, 480-486, 1985. 14) REDMER, D. A., S. MEREDITH, G. D. BALL, A. YANKOWSKY and B. N. DAY: J. Anim. Sci., 49 (Suppl.), 116, 1979. 26) 河原崎達雄・曾根勝・関哲夫・辻岡豊・堀内篤・吉田光敏・番場公雄・田嶋昌夫・川倉一彦: 日豚研誌, 22, 104, 1985. 2) 森純一・富塚常夫: 畜産の研究, 33, 363-369, 1979. 31) 谷中匡・内山京子・佐々木捷彦・湊芳明・浜野光市・吉田敏・百目鬼郁男: 家畜繁殖学会第70回大会講演要旨, 48, 1986. 32) NIWA, T., S. KANEMATSU, T. YANAKA, T. HASHIZUME and H. YAMANAKA: 岩手大農・人工授精研報, 2, 25-31, 1981. 16) O'REILLY, P. J., R. MCCORMACK, K. O. MAHONY, C. MURPHY: Theriogenology, 12, 131-137, 1979. 4) GERRITS, R. J., L. A. JOHNSON: Proc. 5th Int. Cong. Anim. Reprod. and Artifi. Insem., 2, 455-459, Trento, 1964. 24) 菅原七郎・正木淳二・早川秀輝・松井滋・須磨隆・小川宏: 日畜東北支部会報, 34, 21-24, 1984. 5) POLGE, C.: Proc. 5th Int. Cong. Anim. Reprod. and Artifi. Insem., 3, 388-393, Trento, 1964. 10) KING, G. T.: J. Reprod. Fert., 20, 551-553, 1969. 18) PURSEL, V. G., D. O. ELLIOTT, C. W. NEWMAN and R. B. STAIGMILLER: J. Anim. Sci., 52, 130-133, 1981. 15) DAVIS, D. L., J. W. KNIGHT, D. B. KILLIAN and B. N. DAY: J. Anim. Sci., 49, 1506-1509, 1979. 28) 小林博之: 日豚会誌, 24, 121-122, 1987. 3) DAY, B. N.: Proc. 10th Int. Cong. Anim. Reprod. and Artifi. Insem., IV, 1-9, Illinois, 1984. 9) 穴井昭三・酒見武典・重森正美: 日豚研誌, 6, 19, 1969. 8) 丹羽太左衛門・菅原兼太郎・大橋昭也・益子正己・宮原強・田畑正彦・井上和男・篠原信重・白井未吉・栗原一男・石井泰明・福田勤・鹿熊俊明・和田治男・石井雅彦・川上素行・田中章人・高橋明・窺俊定・伊藤菁: 日豚研誌, 6, 19, 1969. 29) REDMER, D. A. and B. N. DAY: J. Anim. Sci., 51 (Suppl. 1), 319-320, 1981. 27) 塩原広之・久保親二・添田益夫・武田光彦・深谷守・杉本輝夫・菅野興文・菅原七郎・亀山賢次・正木淳二: 哺乳卵研誌, 3, 48-49, 1986. 7) 酒井義正・栗原武・八木満寿雄・河上尚実: 日豚研誌, 3, 88, 1966. 20) DAVIS, D. L., J. S. STEVENSON and W. E. SCHMIDT: J. Anim. Sci., 60, 599-602, 1985. 23) 川倉一彦・副島昭彦・桝田博司・石原忠雄: 人工授精研誌, 6, 23, 1984. 13) KNIGHT, J. W., D. L. DAVIS and B. N. DAY: J. Anim. Sci., 42 (Abstr.), 1358, 1976. 17) KRAELING, R. R., P. J. DZIUK, V. G. PURSEL, G. B. RAMPACEK and S. K. WEBEL: J. Anim. Sci., 52, 831-835, 1981. 12) DAVIS, D. L., D. B. KILLIAN and B. N. DAY: J. Anim. Sci., 42 (Abstr.), 1358, 1976. 1) WEBEL, S. K.: Ovulation control in the pig. In Control of Ovulation (D. G. GRIGHTON, N. B. HAYNES, G. R. FOXCROFT and G. E. LAMMING, Ed.), 421-434, Butterworths, London, 1978. 22) DURA, M., J. E. TILTON, AIECIK, R. M. WEIGL and G. L. WILLIAMS: Anim. Reprod. Sci., 14, 147-155, 1987. 19) STEVENSON, J. S. and D. L. DAVIS: J. Anim. Sci., 55, 119-123, 1982. |
| References_xml | – reference: 18) PURSEL, V. G., D. O. ELLIOTT, C. W. NEWMAN and R. B. STAIGMILLER: J. Anim. Sci., 52, 130-133, 1981. – reference: 19) STEVENSON, J. S. and D. L. DAVIS: J. Anim. Sci., 55, 119-123, 1982. – reference: 30) REDMER, D. A. and B. N. DAY: J. Anim. Sci., 53, 1088-1094, 1981. – reference: 5) POLGE, C.: Proc. 5th Int. Cong. Anim. Reprod. and Artifi. Insem., 3, 388-393, Trento, 1964. – reference: 17) KRAELING, R. R., P. J. DZIUK, V. G. PURSEL, G. B. RAMPACEK and S. K. WEBEL: J. Anim. Sci., 52, 831-835, 1981. – reference: 13) KNIGHT, J. W., D. L. DAVIS and B. N. DAY: J. Anim. Sci., 42 (Abstr.), 1358, 1976. – reference: 20) DAVIS, D. L., J. S. STEVENSON and W. E. SCHMIDT: J. Anim. Sci., 60, 599-602, 1985. – reference: 14) REDMER, D. A., S. MEREDITH, G. D. BALL, A. YANKOWSKY and B. N. DAY: J. Anim. Sci., 49 (Suppl.), 116, 1979. – reference: 24) 菅原七郎・正木淳二・早川秀輝・松井滋・須磨隆・小川宏: 日畜東北支部会報, 34, 21-24, 1984. – reference: 3) DAY, B. N.: Proc. 10th Int. Cong. Anim. Reprod. and Artifi. Insem., IV, 1-9, Illinois, 1984. – reference: 1) WEBEL, S. K.: Ovulation control in the pig. In Control of Ovulation (D. G. GRIGHTON, N. B. HAYNES, G. R. FOXCROFT and G. E. LAMMING, Ed.), 421-434, Butterworths, London, 1978. – reference: 2) 森純一・富塚常夫: 畜産の研究, 33, 363-369, 1979. – reference: 26) 河原崎達雄・曾根勝・関哲夫・辻岡豊・堀内篤・吉田光敏・番場公雄・田嶋昌夫・川倉一彦: 日豚研誌, 22, 104, 1985. – reference: 8) 丹羽太左衛門・菅原兼太郎・大橋昭也・益子正己・宮原強・田畑正彦・井上和男・篠原信重・白井未吉・栗原一男・石井泰明・福田勤・鹿熊俊明・和田治男・石井雅彦・川上素行・田中章人・高橋明・窺俊定・伊藤菁: 日豚研誌, 6, 19, 1969. – reference: 32) NIWA, T., S. KANEMATSU, T. YANAKA, T. HASHIZUME and H. YAMANAKA: 岩手大農・人工授精研報, 2, 25-31, 1981. – reference: 21) STEVENSON, J. S., D. L. DAVIS and D. S. POLLMANN: J. Anim. Sci., 61, 480-486, 1985. – reference: 6) POLGE, C.: Vet. Rec., 77, 232-236, 1965. – reference: 22) DURA, M., J. E. TILTON, AIECIK, R. M. WEIGL and G. L. WILLIAMS: Anim. Reprod. Sci., 14, 147-155, 1987. – reference: 10) KING, G. T.: J. Reprod. Fert., 20, 551-553, 1969. – reference: 29) REDMER, D. A. and B. N. DAY: J. Anim. Sci., 51 (Suppl. 1), 319-320, 1981. – reference: 7) 酒井義正・栗原武・八木満寿雄・河上尚実: 日豚研誌, 3, 88, 1966. – reference: 28) 小林博之: 日豚会誌, 24, 121-122, 1987. – reference: 4) GERRITS, R. J., L. A. JOHNSON: Proc. 5th Int. Cong. Anim. Reprod. and Artifi. Insem., 2, 455-459, Trento, 1964. – reference: 15) DAVIS, D. L., J. W. KNIGHT, D. B. KILLIAN and B. N. DAY: J. Anim. Sci., 49, 1506-1509, 1979. – reference: 12) DAVIS, D. L., D. B. KILLIAN and B. N. DAY: J. Anim. Sci., 42 (Abstr.), 1358, 1976. – reference: 16) O'REILLY, P. J., R. MCCORMACK, K. O. MAHONY, C. MURPHY: Theriogenology, 12, 131-137, 1979. – reference: 11) WEBEL, S. K.: J. Anim. Sci., 42 (Abstr.), 1358, 1976. – reference: 9) 穴井昭三・酒見武典・重森正美: 日豚研誌, 6, 19, 1969. – reference: 31) 谷中匡・内山京子・佐々木捷彦・湊芳明・浜野光市・吉田敏・百目鬼郁男: 家畜繁殖学会第70回大会講演要旨, 48, 1986. – reference: 25) 菅原七郎・高木優二・正木淳二・佐藤正勝・川村利明・津志田農・大槻宗生・佐々間福雄・塩原広之・柏崎直己・杉本輝夫・武田光彦: 畜産の研究, 42, 261-264, 1988. – reference: 27) 塩原広之・久保親二・添田益夫・武田光彦・深谷守・杉本輝夫・菅野興文・菅原七郎・亀山賢次・正木淳二: 哺乳卵研誌, 3, 48-49, 1986. – reference: 23) 川倉一彦・副島昭彦・桝田博司・石原忠雄: 人工授精研誌, 6, 23, 1984. |
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| Title | Control of estrus and level of serum progesterone in swine by oral administration of altrenogest |
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