IMMU-10. RADIOTHERAPY AND PD-1 BLOCKADE INCREASES TRYPTOPHAN METABOLISM IN BRAIN TUMOR-DRAINING SECONDARY LYMPHOID ORGANS

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 20; no. suppl_6; p. vi123
• Main Authors: Savoor, Rohan, Ladomersky, Erik, Otto-Meyer, Sebastian, Zhai, Lijie, Lauing, Kristen, Lenzen, Alicia, Lukas, Rimas, Wainwright, Derek
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 05.11.2018
• Subjects: Abstracts

Abstract INTRODUCTION Glioblastoma (GBM) is an aggressive, incurable, primary brain tumor with a median survival of 15–20 months. High intratumoral expression of indoleamine 2,3-dioxygenase 1 (IDO1), an immunosuppressive enzyme that metabolizes tryptophan (Trp) into kynurenine (Kyn), is one factor t...