Review Article: Probiotics-Mediated Enhancement of Checkpoint Inhibitor Blockade for HER2+ Breast Cancer

• Published in: Critical reviews in oncogenesis Vol. 30; no. 2; p. 37
• Main Authors: Ho, Mai, Bonavida, Benjamin
• Format: Journal Article
• Language: English
• Published: United States 2025
• Subjects: Animals; Breast Neoplasms - drug therapy; Breast Neoplasms - immunology; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Female; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - immunology; Humans; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunotherapy - methods; Probiotics - administration & dosage; Probiotics - therapeutic use; Receptor, ErbB-2 - antagonists & inhibitors; Receptor, ErbB-2 - metabolism
• ISSN: 0893-9675
• DOI: 10.1615/CritRevOncog.2025058633

Immune checkpoint inhibitors (ICIs) have significantly improved survival rates for many types of cancer, giving patients survival prognoses that had been previously unattainable. Unfortunately, in many advanced cancers, including breast cancer (BC), objective response rates (ORRs) have been reported...