Role of the late‐onset Alzheimer’s disease risk genes bin1 and ptk2b in the hyperexcitability of hiPSC‐derived neurons

• Published in: Alzheimer's & dementia Vol. 17; pp. e053632 - n/a
• Main Authors: De Farias, Ana‐Raquel Melo, Saha, Orthis, Lambert, Jean‐Charles, Costa, Marcos Romualdo
• Format: Journal Article
• Language: English
• Published: United States 01.12.2021

Background The BIN1 (Bridging Integrator‐1) gene is the second most important Alzheimer’s disease risk gene and has been associated with synaptic transmission defects in animal models. PTK2B (Protein Tyrosine Kinase 2β) is a Ca2+‐activated non‐receptor tyrosine kinase, also identified by genome‐wide...