TLR7/8 Activation in Immune Cells and Muscle by RNA-Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis

• Published in: Arthritis & rheumatology (Hoboken, N.J.)
• Main Authors: Wu, Yin, Deshpande, Aditee, Geraci, Nicholas, Budde, Petra, Sellers, Vera, Velisetty, Phanindra, Sun, Chia-Chi, Strand, Fatima, Bhavsar, Carmina, Niewold, Timothy B, Jensen, Mark A, Kalatskaya, Irina, Sarin, Kavita Y, Fiorentino, David, Bender, Andrew T
• Format: Journal Article
• Language: English
• Published: United States 04.11.2024

Activation of endosomal toll-like receptors (TLRs) is one possible driver of inflammation in idiopathic inflammatory myopathies (IIM). We investigated the potential contribution of TLR7 and TLR8 to IIM pathogenesis. Activation of TLR7/8 in healthy donor peripheral blood mononuclear cells (PBMCs) by...