Central μ-Opioidergic System Activation Evoked by Heavy and Severe-Intensity Cycling Exercise in Humans: a Pilot Study Using Positron Emission Tomography with 11C-Carfentanil

• Published in: International journal of sports medicine Vol. 38; no. 1; p. 19
• Main Authors: Hiura, Mikio, Sakata, Muneyuki, Ishii, Kenji, Toyohara, Jun, Oda, Keiichi, Nariai, Tadashi, Ishiwata, Kiichi
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2017
• Subjects: Affect; Carbon Radioisotopes; Exercise - physiology; Exercise Test; Fatigue; Fentanyl - administration & dosage; Fentanyl - analogs & derivatives; Humans; Limbic System - diagnostic imaging; Limbic System - physiology; Male; Pilot Projects; Positron-Emission Tomography; Receptors, Opioid, mu - physiology; Synaptic Transmission; Young Adult

The central opioid receptor system likely contributes to the mechanism underlying the changes in affect elicited by exercise. Our aim was to use positron emission tomography (PET) to test whether exercise intensity influences activation of the μ-opioid receptor system in the brain, and whether chang...