LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75NTR antagonists

• Published in: Molecular and cellular neuroscience Vol. 45; no. 4; pp. 363 - 369
• Main Authors: Bourikas, Dimitris, Mir, Anis, Walmsley, Adrian Robert
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2010
• Subjects: Antagonists; Leucine-rich repeats; LINGO-1; Myelin basic protein; Oligodendrocyte differentiation; p75NTR; PBS; p75NTR; OPC; Oligodendrocyte differentiation; PMA; MS; EAE; CNS; Leucine-rich repeats; LINGO-1; CNPase; LRR; Myelin basic protein; CG4; PDGFRα; FBS; NgR; IB; MBP; GAPDH; Ig

LINGO-1 is a potent negative regulator of oligodendrocyte differentiation and hence may play a pivotal restrictive role during remyelination in demyelinating diseases such as multiple sclerosis. However, little is known as to which stages of oligodendrocyte differentiation are inhibited by LINGO-1,...