Effects of Cassia auriculata and Cardospermum halicacabum teas on the steady state blood levels of theophylline in rats

The effects of concurrent administration of herbal tea prepared from dried flowers of Cassia auriculata or aerial parts of Cardospermum halicacabum and steady state serum levels of theophylline was investigated in Wistar rats. Results obtained demonstrate that a significant increase in the steady st...

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Bibliographic Details
Published inDrug metabolism and drug interactions Vol. 20; no. 4; p. 263
Main Authors Thabrew, M I, Munasinghe, T M J, Senarath, S, Yapa, R M S C
Format Journal Article
LanguageEnglish
Published Germany 2004
Subjects
Animals
Beverages
Biological Availability
Bronchodilator Agents - blood
Cassia
Chromatography, High Pressure Liquid - methods
Herb-Drug Interactions
Male
Plant Preparations - pharmacology
Rats
Rats, Wistar
Sapindaceae
Theophylline - blood
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Summary:The effects of concurrent administration of herbal tea prepared from dried flowers of Cassia auriculata or aerial parts of Cardospermum halicacabum and steady state serum levels of theophylline was investigated in Wistar rats. Results obtained demonstrate that a significant increase in the steady state levels of theophylline occur when this drug is administered concurrently with herbal tea prepared from either of the above plants. C. auriculata and C. halicacabum enhanced the steady state levels of theophylline by 32.5% (p < 0.02) and 48.2% (p < 0.02), respectively, when compared with the levels in animals receiving theophylline alone for the same time period. Herbal teas prepared from C. auriculata or C. halicacabum should therefore be avoided by patients treated with theophylline as these herbal teas have the potential to influence the bioavailability of the prescription drug.
ISSN:0792-5077
DOI:10.1515/DMDI.2004.20.4.263