Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H 2 O 2 -induced apoptosis in PC12 cells

• Published in: Drug design, development and therapy Vol. 12; pp. 3973 - 3984
• Main Authors: Qi, Shimei, Feng, Zunyong, Li, Qiang, Qi, Zhilin, Zhang, Yao
• Format: Journal Article
• Language: English
• Published: New Zealand 2018
• Subjects: Animals; Apoptosis - drug effects; Cell Survival - drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids - pharmacology; Glucosides - pharmacology; Hydrogen Peroxide - antagonists & inhibitors; Hydrogen Peroxide - pharmacology; Molecular Conformation; PC12 Cells; Proto-Oncogene Proteins c-akt - metabolism; Rats; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; src-Family Kinases - metabolism; Structure-Activity Relationship; orientin; Src; neuroprotection; apoptosis; AKT; oxidative stress; MAPKs

Reactive oxygen species (ROS) are considered a direct cause of neurodegenerative diseases (NDDs). Drugs developed to target ROS are effective for the treatment of NDDs. Orientin is a pyrone glucoside extracted from , and it exhibits many pharmacological activities. In this study, we aimed to determi...