Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H 2 O 2 -induced apoptosis in PC12 cells - Qi, Shimei; Feng, Zunyong; Li, Qiang; Qi, Zhilin; Zhang, Yao (Drug design, development and therapy, 2018)
Keywords: Animals; Apoptosis - drug effects; Cell Survival - drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids - pharmacology; Glucosides - pharmacology; Hydrogen Peroxide - antagonists & inhibitors; Hydrogen Peroxide - pharmacology; Molecular Conformation; PC12 Cells; Proto-Oncogene Proteins c-akt - metabolism; Rats; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; src-Family Kinases - metabolism; Structure-Activity Relationship; orientin; Src; neuroprotection; apoptosis; AKT; oxidative stress; MAPKs