Surveillance of Tick-borne Disease Pathogens in Ticks in Yamagata Prefecture, Japan
To investigate the possibility of tick-borne disease (TBD) occurrence in Yamagata, Japan, we attempted to detect the specific gene of TBD causative pathogens in 158 host-seeking adult ticks and 112 adult ticks biting wild animals in Yamagata from 2016 to 2018. Results revealed that all tick specimen...
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| Published in | Journal of the Japan Veterinary Medical Association Vol. 73; no. 9; pp. 517 - 524 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
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Japan Veterinary Medical Association
20.09.2020
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| Abstract | To investigate the possibility of tick-borne disease (TBD) occurrence in Yamagata, Japan, we attempted to detect the specific gene of TBD causative pathogens in 158 host-seeking adult ticks and 112 adult ticks biting wild animals in Yamagata from 2016 to 2018. Results revealed that all tick specimens were negative for the pathogens' gene of Japanese spotted fever, Lyme disease, tick-borne relapsing fever, tick-borne encephalitis, and severe fever with thrombocytopenia syndrome, all of which have been reported in Japan. In contrast, the specific gene sequence of Rickettsia helvetica was detected from 30 Ixodes monospinosus and a Haemaphysalis japonica. That of Rickettsia monacensis was detected from an Ixodes nipponensis. Results show that TBD known in Japan might not constitute a serious human health threat in Yamagata, but special attention is required to monitor the occurrence of TBD, including ones that have not been reported in Japan. |
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| AbstractList | To investigate the possibility of tick-borne disease (TBD) occurrence in Yamagata, Japan, we attempted to detect the specific gene of TBD causative pathogens in 158 host-seeking adult ticks and 112 adult ticks biting wild animals in Yamagata from 2016 to 2018. Results revealed that all tick specimens were negative for the pathogens' gene of Japanese spotted fever, Lyme disease, tick-borne relapsing fever, tick-borne encephalitis, and severe fever with thrombocytopenia syndrome, all of which have been reported in Japan. In contrast, the specific gene sequence of Rickettsia helvetica was detected from 30 Ixodes monospinosus and a Haemaphysalis japonica. That of Rickettsia monacensis was detected from an Ixodes nipponensis. Results show that TBD known in Japan might not constitute a serious human health threat in Yamagata, but special attention is required to monitor the occurrence of TBD, including ones that have not been reported in Japan. |
| Author | KOJO, Nobuaki MIZUTA, Katsumi NAKAMURA, Yumena IKEDA, Tatsuya SETO, Junji TANAKA, Shizuka HIGASHI, Hideo |
| Author_xml | – sequence: 1 fullname: SETO, Junji organization: Yamagata Prefectural Institute of Public Health – sequence: 2 fullname: HIGASHI, Hideo organization: Wildlife Workshop – sequence: 3 fullname: TANAKA, Shizuka organization: Yamagata Prefectural Institute of Public Health – sequence: 4 fullname: KOJO, Nobuaki organization: Wildlife Partnership Office-Yamagata Dormouse Research Group – sequence: 5 fullname: NAKAMURA, Yumena organization: Wildlife Partnership Office-Yamagata Dormouse Research Group – sequence: 6 fullname: IKEDA, Tatsuya organization: Yamagata Prefectural Institute of Public Health – sequence: 7 fullname: MIZUTA, Katsumi organization: Yamagata Prefectural Institute of Public Health |
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| Cites_doi | 10.1016/S1386-6532(02)00168-3 10.4269/ajtmh.2009.09-0208 10.1038/s41598-018-37836-5 10.3201/eid1902.120856 10.7601/mez.65.13 10.3201/eid2008.131761 10.1111/j.1462-2920.2009.02054.x 10.3201/eid1608.100049 10.1159/000326941 10.1016/j.ttbdis.2017.12.016 10.1093/infdis/jit603 10.1111/mve.12191 10.1292/jvms.18-0017 10.7883/yoken.JJID.2017.447 10.1128/JCM.00742-14 10.1128/CMR.00032-13 10.1128/JCM.01728-17 10.1111/1348-0421.12496 |
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| References | [8] Kawamori F, Shimazu Y, Sato H, Monma N, Ikegaya A, Yamamoto S, Fujita H, Morita H, Tamaki Y, Takamoto N, Su H, Shimada M, Shimamura Y, Masuda S, Ando S, Ohashi N : Evaluation of diagnostic assay for rickettsioses using duplex real-time PCR in multiple laboratories in Japan, Jpn J Infect Dis, 71, 267-273 (2018) [7] Kim YS, Choi YJ, Lee KM, Ahn KJ, Kim HC, Klein T, Jiang J, Richards A, Park KH, Jang WJ : First isolation of Rickettsia monacensis from a patient in South Korea, Microbiol Immunol, 61, 258-263 (2017) [10] Schwaiger M, Cassinotti P : Development of a quantitative real-time RT-PCR assay with internal control for the laboratory detection of tick borne encephalitis virus (TBEV) RNA, J Clin Virol, 27, 136-145 (2003) [12] 江原昭三：マダニ科，日本ダニ類図鑑，江原昭三編，第1版，145-161，全国農村教育協会，東京（1980） [6] Imaoka K, Kaneko S, Tabara K, Kusatake K, Morita E : The first human case of Rickettsia tamurae infection in Japan, Case Reports in Dermatology, 3, 68-73 (2011) [1] Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M : The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan, J Infect Dis, 209, 816-827 (2014) [19] 山口 昇：日本産マダニ上科の検索，ダニ学の進歩，佐々 學編，第1版，451-472，北隆館，東京（1977） [9] Barbour AG, Bunikis J, Travinsky B, Hoen AG, Diuk-Wasser MA, Fish D, Tsao JI : Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species, Am J Trop Med Hyg, 81, 1120-1131 (2009) [15] Uchida L, Hayasaka D, Ngwe Tun MM, Morita K, Muramatsu Y, Hagiwara K : Survey of tick-borne zoonotic viruses in wild deer in Hokkaido, Japan, J Vet Med Sci, 80, 985-988 (2018) [2] Sato K, Takano A, Konnai S, Nakao M, Ito T, Koyama K, Kaneko M, Ohnishi M, Kawabata H : Human infections with Borrelia miyamotoi, Japan, Emerg Infect Dis, 20, 1391-1393 (2014) [4] Parola P, Paddock CD, Socolovschi C, Labruna MB, Mediannikov O, Kernif T, Abdad MY, Stenos J, Bitam I, Fournier PE, Raoult D : Update on tick-borne rickettsioses around the world: a geographic approach, Clin Microbiol Rev, 26, 657-702 (2013) [13] Roome A, Hill L, Al-Feghali V, Murnock CG, Goodsell JA, Spathis R, Garruto RM : Impact of white-tailed deer on the spread of Borrelia burgdorferi, Med Vet Entomol, 31, 1-5 (2017) [22] Takano A, Goka K, Une Y, Shimada Y, Fujita H, Shiino T, Watanabe H, Kawabata H : Isolation and characterization of a novel Borrelia group of tick-borne borreliae from imported reptiles and their associated ticks, Environ Microbiol, 12, 134-146 (2010) [3] Abdad MY, Abou Abdallah R, Fournier PE, Stenos J, Vasoo S : A concise review of the epidemiology and diagnostics of rickettsioses: Rickettsia and Orientia spp., J Clin Microbiol, 56, e01728-17 (2018), (online), (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062794/), (accessed 2019-07-30) [25] 佐藤 梢，高野 愛，高娃，安藤秀二，川端寛樹：ダニ媒介感染症 ─国内に常在する感染症を主に─，衛生動物，70，3-14（2019） [18] 西條政幸：重症熱性血小板減少症候群（SFTS）研究の話題，ウイルス，68，41-50（2018） [23] Takano A, Toyomane K, Konnai S, Ohashi K, Nakao M, Ito T, Andoh M, Maeda K, Watarai M, Sato K, Kawabata H : Tick surveillance for relapsing fever spirochete Borrelia miyamotoi in Hokkaido, Japan, PLoS One, 9, e104532 (2014), (online), (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104532), (accessed 2019-07-30) [11] Yoshikawa T, Fukushi S, Tani H, Fukuma A, Taniguchi S, Toda S, Shimazu Y, Yano K, Morimitsu T, Ando K, Yoshikawa A, Kan M, Kato N, Motoya T, Kuzuguchi T, Nishino Y, Osako H, Yumisashi T, Kida K, Suzuki F, Takimoto H, Kitamoto H, Maeda K, Takahashi T, Yamagishi T, Oishi K, Morikawa S, Saijo M, Shimojima M : Sensitive and specific PCR systems for detection of both Chinese and Japanese severe fever with thrombocytopenia syndrome virus strains and prediction of patient survival based on viral load, J Clin Microbiol, 52, 3325-3333 (2014) [5] Ando S, Kurosawa M, Sakata A, Fujita H, Sakai K, Sekine M, Katsumi M, Saitou W, Yano Y, Takada N, Takano A, Kawabata H, Hanaoka N, Watanabe H, Kurane I, Kishimoto T : Human Rickettsia heilongjiangensis infection, Japan, Emerg Infect Dis, 16, 1306-1308 (2010) [16] Kumagai Y, Sato K, Taylor KR, Zamoto-Niikura A, Imaoka K, Morikawa S, Ohnishi M, Kawabata H : A relapsing fever group Borrelia sp. is widely distributed among wild deer in Japan, Ticks Tick-Borne Dis, 9, 465-470 (2018) [14] 田原研司，藤澤直輝，山田直子，三田哲朗，金森弘樹：島根半島弥山山地におけるニホンジカ密度管理による日本紅斑熱発生リスクの減少，衛生動物，70，79-82（2019） [24] Furuno K, Lee K, Itoh Y, Suzuki K, Yonemitsu K, Kuwata R, Shimoda H, Watarai M, Maeda K, Takano A : Epidemiological study of relapsing fever borreliae detected in Haemaphysalis ticks and wild animals in the western part of Japan, PLoS One, 12, e0174727 (2017), (online), (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174727), (accessed 2019-07-30) [17] Thu MJ, Qiu Y, Matsuno K, Kajihara M, Mori-Kajihara A, Omori R, Monma N, Chiba K, Seto J, Gokuden M, Andoh M, Oosako H, Katakura K, Takada A, Sugimoto C, Isoda N, Nakao R : Diversity of spotted fever group rickettsiae and their association with host ticks in Japan, Sci Rep, 9, 1500 (2019) [20] Takano A, Fujita H, Kadosaka T, Takahashi M, Yamauchi T, Ishiguro F, Takada N, Yano Y, Oikawa Y, Honda T, Gokuden M, Tsunoda T, Tsurumi M, Ando S, Andoh M, Sato K, Kawabata H : Construction of a DNA database for ticks collected in Japan: application of molecular identication based on the mitochondrial 16S rDNA gene, Medical Entomology and Zoology, 65, 13-21 (2014) [21] Gaowa, Ohashi N, Aochi M, Wuritu, Wu D, Yoshikawa Y, Kawamori F, Honda T, Fujita H, Takada N, Oikawa Y, Kawabata H, Ando S, Kishimoto T : Rickettsiae in ticks, Japan, 2007-2011, Emerg Infect Dis, 19, 338-340 (2013) 11 12 13 14 15 16 17 18 19 1 2 3 4 5 6 7 8 9 20 10 |
| References_xml | – reference: [13] Roome A, Hill L, Al-Feghali V, Murnock CG, Goodsell JA, Spathis R, Garruto RM : Impact of white-tailed deer on the spread of Borrelia burgdorferi, Med Vet Entomol, 31, 1-5 (2017) – reference: [8] Kawamori F, Shimazu Y, Sato H, Monma N, Ikegaya A, Yamamoto S, Fujita H, Morita H, Tamaki Y, Takamoto N, Su H, Shimada M, Shimamura Y, Masuda S, Ando S, Ohashi N : Evaluation of diagnostic assay for rickettsioses using duplex real-time PCR in multiple laboratories in Japan, Jpn J Infect Dis, 71, 267-273 (2018) – reference: [12] 江原昭三：マダニ科，日本ダニ類図鑑，江原昭三編，第1版，145-161，全国農村教育協会，東京（1980） – reference: [22] Takano A, Goka K, Une Y, Shimada Y, Fujita H, Shiino T, Watanabe H, Kawabata H : Isolation and characterization of a novel Borrelia group of tick-borne borreliae from imported reptiles and their associated ticks, Environ Microbiol, 12, 134-146 (2010) – reference: [15] Uchida L, Hayasaka D, Ngwe Tun MM, Morita K, Muramatsu Y, Hagiwara K : Survey of tick-borne zoonotic viruses in wild deer in Hokkaido, Japan, J Vet Med Sci, 80, 985-988 (2018) – reference: [2] Sato K, Takano A, Konnai S, Nakao M, Ito T, Koyama K, Kaneko M, Ohnishi M, Kawabata H : Human infections with Borrelia miyamotoi, Japan, Emerg Infect Dis, 20, 1391-1393 (2014) – reference: [14] 田原研司，藤澤直輝，山田直子，三田哲朗，金森弘樹：島根半島弥山山地におけるニホンジカ密度管理による日本紅斑熱発生リスクの減少，衛生動物，70，79-82（2019） – reference: [19] 山口 昇：日本産マダニ上科の検索，ダニ学の進歩，佐々 學編，第1版，451-472，北隆館，東京（1977） – reference: [6] Imaoka K, Kaneko S, Tabara K, Kusatake K, Morita E : The first human case of Rickettsia tamurae infection in Japan, Case Reports in Dermatology, 3, 68-73 (2011) – reference: [23] Takano A, Toyomane K, Konnai S, Ohashi K, Nakao M, Ito T, Andoh M, Maeda K, Watarai M, Sato K, Kawabata H : Tick surveillance for relapsing fever spirochete Borrelia miyamotoi in Hokkaido, Japan, PLoS One, 9, e104532 (2014), (online), (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104532), (accessed 2019-07-30) – reference: [10] Schwaiger M, Cassinotti P : Development of a quantitative real-time RT-PCR assay with internal control for the laboratory detection of tick borne encephalitis virus (TBEV) RNA, J Clin Virol, 27, 136-145 (2003) – reference: [3] Abdad MY, Abou Abdallah R, Fournier PE, Stenos J, Vasoo S : A concise review of the epidemiology and diagnostics of rickettsioses: Rickettsia and Orientia spp., J Clin Microbiol, 56, e01728-17 (2018), (online), (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062794/), (accessed 2019-07-30) – reference: [16] Kumagai Y, Sato K, Taylor KR, Zamoto-Niikura A, Imaoka K, Morikawa S, Ohnishi M, Kawabata H : A relapsing fever group Borrelia sp. is widely distributed among wild deer in Japan, Ticks Tick-Borne Dis, 9, 465-470 (2018) – reference: [18] 西條政幸：重症熱性血小板減少症候群（SFTS）研究の話題，ウイルス，68，41-50（2018） – reference: [24] Furuno K, Lee K, Itoh Y, Suzuki K, Yonemitsu K, Kuwata R, Shimoda H, Watarai M, Maeda K, Takano A : Epidemiological study of relapsing fever borreliae detected in Haemaphysalis ticks and wild animals in the western part of Japan, PLoS One, 12, e0174727 (2017), (online), (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174727), (accessed 2019-07-30) – reference: [7] Kim YS, Choi YJ, Lee KM, Ahn KJ, Kim HC, Klein T, Jiang J, Richards A, Park KH, Jang WJ : First isolation of Rickettsia monacensis from a patient in South Korea, Microbiol Immunol, 61, 258-263 (2017) – reference: [17] Thu MJ, Qiu Y, Matsuno K, Kajihara M, Mori-Kajihara A, Omori R, Monma N, Chiba K, Seto J, Gokuden M, Andoh M, Oosako H, Katakura K, Takada A, Sugimoto C, Isoda N, Nakao R : Diversity of spotted fever group rickettsiae and their association with host ticks in Japan, Sci Rep, 9, 1500 (2019) – reference: [1] Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M : The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan, J Infect Dis, 209, 816-827 (2014) – reference: [21] Gaowa, Ohashi N, Aochi M, Wuritu, Wu D, Yoshikawa Y, Kawamori F, Honda T, Fujita H, Takada N, Oikawa Y, Kawabata H, Ando S, Kishimoto T : Rickettsiae in ticks, Japan, 2007-2011, Emerg Infect Dis, 19, 338-340 (2013) – reference: [11] Yoshikawa T, Fukushi S, Tani H, Fukuma A, Taniguchi S, Toda S, Shimazu Y, Yano K, Morimitsu T, Ando K, Yoshikawa A, Kan M, Kato N, Motoya T, Kuzuguchi T, Nishino Y, Osako H, Yumisashi T, Kida K, Suzuki F, Takimoto H, Kitamoto H, Maeda K, Takahashi T, Yamagishi T, Oishi K, Morikawa S, Saijo M, Shimojima M : Sensitive and specific PCR systems for detection of both Chinese and Japanese severe fever with thrombocytopenia syndrome virus strains and prediction of patient survival based on viral load, J Clin Microbiol, 52, 3325-3333 (2014) – reference: [25] 佐藤 梢，高野 愛，高娃，安藤秀二，川端寛樹：ダニ媒介感染症 ─国内に常在する感染症を主に─，衛生動物，70，3-14（2019） – reference: [9] Barbour AG, Bunikis J, Travinsky B, Hoen AG, Diuk-Wasser MA, Fish D, Tsao JI : Niche partitioning of Borrelia burgdorferi and Borrelia miyamotoi in the same tick vector and mammalian reservoir species, Am J Trop Med Hyg, 81, 1120-1131 (2009) – reference: [4] Parola P, Paddock CD, Socolovschi C, Labruna MB, Mediannikov O, Kernif T, Abdad MY, Stenos J, Bitam I, Fournier PE, Raoult D : Update on tick-borne rickettsioses around the world: a geographic approach, Clin Microbiol Rev, 26, 657-702 (2013) – reference: [5] Ando S, Kurosawa M, Sakata A, Fujita H, Sakai K, Sekine M, Katsumi M, Saitou W, Yano Y, Takada N, Takano A, Kawabata H, Hanaoka N, Watanabe H, Kurane I, Kishimoto T : Human Rickettsia heilongjiangensis infection, Japan, Emerg Infect Dis, 16, 1306-1308 (2010) – reference: [20] Takano A, Fujita H, Kadosaka T, Takahashi M, Yamauchi T, Ishiguro F, Takada N, Yano Y, Oikawa Y, Honda T, Gokuden M, Tsunoda T, Tsurumi M, Ando S, Andoh M, Sato K, Kawabata H : Construction of a DNA database for ticks collected in Japan: application of molecular identication based on the mitochondrial 16S rDNA gene, Medical Entomology and Zoology, 65, 13-21 (2014) – ident: 10 doi: 10.1016/S1386-6532(02)00168-3 – ident: 9 doi: 10.4269/ajtmh.2009.09-0208 – ident: 15 doi: 10.1038/s41598-018-37836-5 – ident: 17 doi: 10.3201/eid1902.120856 – ident: 16 doi: 10.7601/mez.65.13 – ident: 2 doi: 10.3201/eid2008.131761 – ident: 19 – ident: 18 doi: 10.1111/j.1462-2920.2009.02054.x – ident: 5 doi: 10.3201/eid1608.100049 – ident: 6 doi: 10.1159/000326941 – ident: 14 doi: 10.1016/j.ttbdis.2017.12.016 – ident: 1 doi: 10.1093/infdis/jit603 – ident: 12 doi: 10.1111/mve.12191 – ident: 13 doi: 10.1292/jvms.18-0017 – ident: 8 doi: 10.7883/yoken.JJID.2017.447 – ident: 11 doi: 10.1128/JCM.00742-14 – ident: 4 doi: 10.1128/CMR.00032-13 – ident: 20 – ident: 3 doi: 10.1128/JCM.01728-17 – ident: 7 doi: 10.1111/1348-0421.12496 |
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| Snippet | To investigate the possibility of tick-borne disease (TBD) occurrence in Yamagata, Japan, we attempted to detect the specific gene of TBD causative pathogens... |
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| Title | Surveillance of Tick-borne Disease Pathogens in Ticks in Yamagata Prefecture, Japan |
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| ispartofPNX | Journal of the Japan Veterinary Medical Association, 2020/09/20, Vol.73(9), pp.517-524 |
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