Reactions of oxaprozin-1-O-acyl glucuronide in solutions of human plasma and albumin

• Published in: Advances in experimental medicine and biology Vol. 197; p. 431
• Main Authors: Ruelius, H W, Kirkman, S K, Young, E M, Janssen, F W
• Format: Journal Article
• Language: English
• Published: United States 1986
• Subjects: Carbon Radioisotopes; Humans; Hydrolysis; Kinetics; Oxaprozin; Propionates - blood; Protein Binding; Serum Albumin - metabolism; Uridine Diphosphate Glucuronic Acid - blood; Uridine Diphosphate Sugars - blood

Hydrolysis and rearrangement (isomerization by acyl migration) of oxaprozin glucuronide are greatly accelerated by plasma and human serum albumin. Albumin accounts for all the hydrolytic activity in plasma and no esterase is involved. The isomeric esters formed by rearrangement are also good substra...