Restricted Boltzmann Machines for Classification of Hepatocellular Carcinoma
Multiple antigen miniarrays can provide accurate tools for cancer detection and diagnosis. These miniarrays can be validated by examining their operating characteristics in classifying individuals as either cancer patients or normal (non-cancer) subjects. We describe the use of restricted Boltzmann...
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Published in | Computational Biology Journal Vol. 2014; no. 2014; pp. 1 - 5 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Cairo, Egypt
Hindawi Puplishing Corporation
14.04.2014
Hindawi Publishing Corporation |
Online Access | Get full text |
ISSN | 2314-4165 2314-4173 |
DOI | 10.1155/2014/418069 |
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Abstract | Multiple antigen miniarrays can provide accurate tools for cancer detection and diagnosis. These miniarrays can be validated by examining their operating characteristics in classifying individuals as either cancer patients or normal (non-cancer) subjects. We describe the use of restricted Boltzmann machines for this classification problem, relative to diagnosis of hepatocellular carcinoma. In this setting, we find that its operating characteristics are similar to a logistic regression standard and suggest that restricted Boltzmann machines merit further consideration for classification problems. |
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AbstractList | Multiple antigen miniarrays can provide accurate tools for cancer detection and diagnosis. These miniarrays can be validated by examining their operating characteristics in classifying individuals as either cancer patients or normal (non-cancer) subjects. We describe the use of restricted Boltzmann machines for this classification problem, relative to diagnosis of hepatocellular carcinoma. In this setting, we find that its operating characteristics are similar to a logistic regression standard and suggest that restricted Boltzmann machines merit further consideration for classification problems. |
Author | Koziol, James A. Zhang, Jian-Ying Dai, Liping Tan, Eng M. Ren, Pengfei |
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CitedBy_id | crossref_primary_10_3389_fonc_2016_00149 crossref_primary_10_1109_ACCESS_2017_2728010 crossref_primary_10_1007_s00262_018_2135_y crossref_primary_10_1007_s00521_016_2628_6 crossref_primary_10_1016_j_engappai_2018_09_010 |
Cites_doi | 10.1172/JCI200114451 10.1162/089976602760128018 10.1038/sj.onc.1201110 10.1172/JCI116848 10.1084/jem.189.7.1101 10.1111/j.1600-065X.2008.00611.x 10.1038/sj.onc.1205625 10.1016/j.patcog.2013.05.025 10.1128/MCB.19.2.1262 10.1126/science.1127647 10.1186/1471-2288-12-21 10.1007/978-3-642-33275-3_2 10.3174/ajnr.A2425 |
ContentType | Journal Article |
Contributor | Koziol, James A Zhang, Jian-Ying Tan, Eng M Dai, Liping Ren, Pengfei |
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Copyright | Copyright © 2014 James A. Koziol et al. |
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References | (2) 2002; 14 (9) 1993; 92 (16) 2008; 222 (10) 2006; 16 Ng A. Y. Jordan M. I. Diettrich T. G. Becker S. Ghahramani Z. On discriminative vs. generative classifiers: a comparison of logistic regression and naïve Bayes Advances in Neural Information Processing Systems 2001 Cambridge, Mass, USA MIT Press 841 848 (18) 2012; 12, article 21 (8) 1999; 19 (5) 2014; 47 Fischer A. Igel C. Alvarez L. An introduction to restricted Boltzmann machines Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications 2012 7441 Berlin, Germany Springer 14 36 Lecture Notes in Computer Science (3) 2006; 313 (7) 1997; 14 (15) 2001; 108 (1) 2003; 9 (6) 1999; 189 (11) 2002; 21 (17) 2011; 32 Hinton G. E. A practical guide to training restricted Boltzmann machines 2010 UTML TR 2010-003 Department of Computer Science, University of Toront http://www.csri.utoronto.ca/~hinton/absps/guideTR.pdf Larochelle H. Bengio Y. Classification using discriminative restricted boltzmann machines Proceedings of the 25th International Conference on Machine Learning July 2008 New York, NY, USA ACM 536 543 2-s2.0-56449110012 14 15 18 19 (2) 2012; 7441 (16) 2001 (10) 2003; 9 1 4 5 6 (3) 2014; 47 (17) 1999; 19 (12) 2006; 16 8 |
References_xml | – volume: 9 start-page: 5120 issue: 14 year: 2003 end-page: 5126 ident: 1 article-title: Recursive partitioning as an approach to selection of immune markers for tumor diagnosis – volume: 189 start-page: 1101 issue: 7 year: 1999 end-page: 1110 ident: 6 article-title: A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma – reference: Larochelle H. Bengio Y. Classification using discriminative restricted boltzmann machines Proceedings of the 25th International Conference on Machine Learning July 2008 New York, NY, USA ACM 536 543 2-s2.0-56449110012 – volume: 14 start-page: 2729 issue: 22 year: 1997 end-page: 2733 ident: 7 article-title: Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein – volume: 32 start-page: 437 issue: 3 year: 2011 end-page: 440 ident: 17 article-title: Analysis by categorizing or dichotomizing continuous variables is inadvisable: an example from the natural history of unruptured aneurysms – reference: Ng A. Y. Jordan M. I. Diettrich T. G. Becker S. Ghahramani Z. On discriminative vs. generative classifiers: a comparison of logistic regression and naïve Bayes Advances in Neural Information Processing Systems 2001 Cambridge, Mass, USA MIT Press 841 848 – volume: 47 start-page: 25 year: 2014 end-page: 39 ident: 5 article-title: Training restricted Boltzmann machines: an introduction – volume: 222 start-page: 328 issue: 1 year: 2008 end-page: 340 ident: 16 article-title: Autoantibodies to tumor-associated antigens: reporters from the immune system – reference: Hinton G. E. A practical guide to training restricted Boltzmann machines 2010 UTML TR 2010-003 Department of Computer Science, University of Toront http://www.csri.utoronto.ca/~hinton/absps/guideTR.pdf – volume: 16 start-page: 1105 issue: 5 year: 2006 end-page: 1110 ident: 10 article-title: Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies – volume: 12, article 21 year: 2012 ident: 18 article-title: Against Quantiles: categorization of continuous variables in epidemiologic research, and its discontents – volume: 19 start-page: 1262 issue: 2 year: 1999 end-page: 1270 ident: 8 article-title: A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development – reference: Fischer A. Igel C. Alvarez L. An introduction to restricted Boltzmann machines Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications 2012 7441 Berlin, Germany Springer 14 36 Lecture Notes in Computer Science – volume: 14 start-page: 1771 issue: 8 year: 2002 end-page: 1800 ident: 2 article-title: Training products of experts by minimizing contrastive divergence – volume: 92 start-page: 2419 issue: 5 year: 1993 end-page: 2426 ident: 9 article-title: Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma – volume: 21 start-page: 5006 issue: 32 year: 2002 end-page: 5015 ident: 11 article-title: Cloning and characterization of a novel 90 kDa “companion” auto-antigen of p62 overexpressed in cancer – volume: 313 start-page: 504 issue: 5786 year: 2006 end-page: 507 ident: 3 article-title: Reducing the dimensionality of data with neural networks – volume: 108 start-page: 1411 issue: 10 year: 2001 end-page: 1415 ident: 15 article-title: Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis – ident: 4 doi: 10.1172/JCI200114451 – ident: 6 doi: 10.1162/089976602760128018 – volume: 16 start-page: 1105 issue: 5 year: 2006 ident: 12 publication-title: Oncology Reports – ident: 14 doi: 10.1038/sj.onc.1201110 – volume: 92 start-page: 2419 issue: 5 year: 1993 ident: 9 publication-title: The Journal of Clinical Investigation doi: 10.1172/JCI116848 – ident: 19 doi: 10.1084/jem.189.7.1101 – start-page: 841 volume-title: On discriminative vs. generative classifiers: a comparison of logistic regression and naïve Bayes year: 2001 ident: 16 – volume: 9 start-page: 5120 issue: 14 year: 2003 ident: 10 publication-title: Clinical Cancer Research – ident: 5 doi: 10.1111/j.1600-065X.2008.00611.x – ident: 18 doi: 10.1038/sj.onc.1205625 – volume: 47 start-page: 25 year: 2014 ident: 3 publication-title: Pattern Recognition doi: 10.1016/j.patcog.2013.05.025 – volume: 19 start-page: 1262 issue: 2 year: 1999 ident: 17 publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.19.2.1262 – ident: 8 doi: 10.1126/science.1127647 – ident: 1 doi: 10.1186/1471-2288-12-21 – volume: 7441 start-page: 14 volume-title: An introduction to restricted Boltzmann machines year: 2012 ident: 2 doi: 10.1007/978-3-642-33275-3_2 – ident: 15 doi: 10.3174/ajnr.A2425 |
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