Increase of Liver Organ Weight in B6C3F1 Mice Fed with High dose Stevioside for 14 Days

Stevioside, a natural sweeteners presently used in various kinds of food and food products in Korea, was evaluated for its toxicity potential in the 14 day feeding study using B6C3F1 mice. Stevioside was added to the diet at different concentrations of 0.31, 0.62, 1.25, 2.5 and 5%, and was administe...

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Bibliographic Details
Published inHan'gug sigpum wi'saeng anjeonseong haghoeji Vol. 27; no. 3
Main Authors Lee, H.Y., Biotoxtech Co., Ltd., Cheongwon, Republic of Korea, Kang, J.K., Chungbuk National University, Cheongju, Republic of Korea, Bang, I.S., Hoseo University, Asan, Republic of Korea, Park, C.B., Hoseo University, Asan, Republic of Korea
Format Journal Article
LanguageEnglish
Published 30.09.2012
Subjects
chronic study
EDULCORANT
EDULCORANTES
MICE
RATON
SOURIS
SWEETENERS
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Summary:Stevioside, a natural sweeteners presently used in various kinds of food and food products in Korea, was evaluated for its toxicity potential in the 14 day feeding study using B6C3F1 mice. Stevioside was added to the diet at different concentrations of 0.31, 0.62, 1.25, 2.5 and 5%, and was administered for 14 consecutive days. An increase of liver organ weight in male mice was observed. No diet-related differences were noted in clinical signs, food consumption, and gross and histopatholgical evaluation. Based on these results, we concluded that the concentration of 5% in the diet was a suitable maximum tolerable dose of stevioside for a 90 day study in mice.
Bibliography:Q01
ISSN:1229-1153
DOI:10.13103/JFHS.2012.27.3.306