The role of miRNA in kidney development

MicroRNAs (miRNAs) are endogenous small non-coding RNAs (19-25 nucleotides) that negatively regulate gene expression at the post transcriptional level by binding to complementary target sequences in the target mRNA. miRNAs play an important role in a wide range of biological processes, including org...

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Bibliographic Details
Published inYíchuán Vol. 42; no. 11; p. 1062
Main Authors Zhao, Xiao Qi, Ao, Ying, Chen, Hai Yun, Wang, Hui
Format Journal Article
LanguageChinese
Published China 20.11.2020
Subjects
Gene Expression Regulation, Developmental - genetics
Humans
Kidney - embryology
Kidney Diseases - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
microRNAs
diagnosis
kidney development
mechanism
kidney dysplasia
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Summary:MicroRNAs (miRNAs) are endogenous small non-coding RNAs (19-25 nucleotides) that negatively regulate gene expression at the post transcriptional level by binding to complementary target sequences in the target mRNA. miRNAs play an important role in a wide range of biological processes, including organ development. Recent studies have shown that some miRNAs are highly expressed in the kidney and are closely related to kidney development and diseases, suggesting that miRNAs are important regulators in kidney physiology and pathology. This review will focus on the research progress of miRNA in kidney development, and discuss the role of miRNAs in the occurrence and development of renal dysplasia, which will provide a reference for the diagnosis and research of diseases related to kidney development.
ISSN:0253-9772
DOI:10.16288/j.yczz.20-112