Towards methylation-based redefinition of TAL1 positive T-cell acute lymphoblastic leukaemia (T-ALL)

• Published in: Leukemia
• Main Authors: Smith, Charlotte, Charbonnier, Guillaume, Simonin, Mathieu, Balducci, Estelle, Steimle, Thomas, Andrieu, Guillaume P., Cieslak, Agata, Courgeon, Marianne, LeLorc’h, Marc, Mayakonda, Anand, Plass, Christoph, Le Nezet, Aurélie, Latiri, Mehdi, Ifrah, Norbert, Dombret, Hervé, Huguet, Françoise, Baruchel, André, Macintyre, Elizabeth, Petit, Arnaud, Boissel, Nicolas, Asnafi, Vahid, Touzart, Aurore
• Format: Journal Article
• Language: English
• Published: England 08.08.2025

TAL1 is one of the most frequently dysregulated oncogenes in T-cell Acute Lymphoblastic Leukaemia (T-ALL). However, the precise frequency and prognostic impact associated with its dysregulation remains unclear and is confounded by TAL1's diverse dysregulation mechanisms. TAL1 dysregulation is d...