Novel Strategies to Effectively De-escalate Curative-Intent Therapy for Patients With HPV-Associated Oropharyngeal Cancer: Current and Future Directions
The treatment of patients with HPV-associated oropharyngeal cancer (HPV-OPC) is rapidly evolving and challenging the standard of care of definitive radiotherapy with concurrent cisplatin. There are numerous promising de-escalation strategies under investigation, including deintensified definitive ch...
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Published in | American Society of Clinical Oncology educational book Vol. 40; p. 1 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
01.03.2020
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Abstract | The treatment of patients with HPV-associated oropharyngeal cancer (HPV-OPC) is rapidly evolving and challenging the standard of care of definitive radiotherapy with concurrent cisplatin. There are numerous promising de-escalation strategies under investigation, including deintensified definitive chemoradiotherapy, transoral surgery followed by de-escalated adjuvant therapy, and induction chemotherapy followed by de-escalated locoregional therapy. Definitive radiotherapy alone or with cetuximab is not recommended for curative-intent treatment of patients with locally advanced HPV-OPC. The results of ongoing phase III studies are awaited to help answer key questions and address ongoing controversies to transform the treatment of patients with HPV-OPC. Strategies for de-escalation under investigation include the incorporation of immunotherapy and the use of novel biomarkers for patient selection for de-escalation. |
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AbstractList | The treatment of patients with HPV-associated oropharyngeal cancer (HPV-OPC) is rapidly evolving and challenging the standard of care of definitive radiotherapy with concurrent cisplatin. There are numerous promising de-escalation strategies under investigation, including deintensified definitive chemoradiotherapy, transoral surgery followed by de-escalated adjuvant therapy, and induction chemotherapy followed by de-escalated locoregional therapy. Definitive radiotherapy alone or with cetuximab is not recommended for curative-intent treatment of patients with locally advanced HPV-OPC. The results of ongoing phase III studies are awaited to help answer key questions and address ongoing controversies to transform the treatment of patients with HPV-OPC. Strategies for de-escalation under investigation include the incorporation of immunotherapy and the use of novel biomarkers for patient selection for de-escalation. |
Author | Nichols, Anthony C Palma, David A Chera, Bhisham S Lang, Pencilla Rosenberg, Ari J Agrawal, Nishant Shen, Colette J Price, Katharine A R Rammal, Almoaidbellah |
Author_xml | – sequence: 1 givenname: Katharine A R surname: Price fullname: Price, Katharine A R organization: Division of Medical Oncology, Mayo Clinic, Rochester, MN – sequence: 2 givenname: Anthony C surname: Nichols fullname: Nichols, Anthony C organization: Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada – sequence: 3 givenname: Colette J surname: Shen fullname: Shen, Colette J organization: Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC – sequence: 4 givenname: Almoaidbellah surname: Rammal fullname: Rammal, Almoaidbellah organization: Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada – sequence: 5 givenname: Pencilla surname: Lang fullname: Lang, Pencilla organization: Division of Radiation Oncology, Department of Oncology, University of Western Ontario, London, Ontario, Canada – sequence: 6 givenname: David A surname: Palma fullname: Palma, David A organization: Division of Radiation Oncology, Department of Oncology, University of Western Ontario, London, Ontario, Canada – sequence: 7 givenname: Ari J surname: Rosenberg fullname: Rosenberg, Ari J organization: Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL – sequence: 8 givenname: Bhisham S surname: Chera fullname: Chera, Bhisham S organization: Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC – sequence: 9 givenname: Nishant surname: Agrawal fullname: Agrawal, Nishant organization: Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Chicago, Chicago, IL |
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Title | Novel Strategies to Effectively De-escalate Curative-Intent Therapy for Patients With HPV-Associated Oropharyngeal Cancer: Current and Future Directions |
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