86Y-DOTA0)-D-Phe1-Tyr3-octreotide (SMT487)--a phase 1 clinical study: pharmacokinetics, biodistribution and renal protective effect of different regimens of amino acid co-infusion

• Published in: European journal of nuclear medicine and molecular imaging Vol. 30; no. 4; pp. 510 - 518
• Main Authors: Jamar, François, Barone, Raffaella, Mathieu, Isabelle, Walrand, Stéphan, Labar, Daniel, Carlier, Pascal, de Camps, Joëlle, Schran, Horst, Chen, TianLing, Smith, M Charles, Bouterfa, Hakim, Valkema, Roelf, Krenning, Eric P, Kvols, Larry K, Pauwels, Stanislas
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.04.2003
• Subjects: Adult; Aged; Amino Acids - administration & dosage; Amino Acids - adverse effects; Arginine - administration & dosage; Cohort Studies; Cross-Over Studies; Dizziness - etiology; Drug Combinations; Female; Humans; Infusions, Intravenous; Kidney - drug effects; Kidney - metabolism; Lysine - administration & dosage; Male; Metabolic Clearance Rate; Middle Aged; Neuroendocrine Tumors - diagnostic imaging; Neuroendocrine Tumors - metabolism; Octreotide - adverse effects; Octreotide - analogs & derivatives; Octreotide - blood; Octreotide - pharmacokinetics; Octreotide - urine; Organ Specificity; Radiation Dosage; Radiation Injuries - etiology; Radiation-Protective Agents - administration & dosage; Radiation-Protective Agents - adverse effects; Radiometry - methods; Radiopharmaceuticals - pharmacokinetics; Tissue Distribution; Tomography, Emission-Computed; Vomiting - etiology; Yttrium Radioisotopes - adverse effects; Yttrium Radioisotopes - blood; Yttrium Radioisotopes - pharmacokinetics; Yttrium Radioisotopes - urine

The pharmacokinetics and dosimetry of (86)Y-DOTA(0)- d-Phe(1)-Tyr(3)-octreotide ((86)Y-SMT487) were evaluated in a phase I positron emission tomography (PET) study of 24 patients with somatostatin receptor-positive neuroendocrine tumours. The effect of amino acid (AA) co-infusion on renal and tumour...