Periorbital necrobiotic xanthogranuloma without paraproteinemia

Introduction: Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disease which most frequently involves periorbital areas. NXG is associated with paraproteinemia with a ratio over 80%. However, a few cases of NXG without paraproteinemia (isolated NXG) have also been reported. Main observation:...

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Published inNasza dermatologia online Vol. 4; no. 3; pp. 341 - 343
Main Authors Nakamura-Wakatsuki, Taeko, Yamamoto, Toshiyuki
Format Journal Article
LanguageEnglish
Published Slupsk Our Dermatology Online 01.07.2013
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Abstract Introduction: Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disease which most frequently involves periorbital areas. NXG is associated with paraproteinemia with a ratio over 80%. However, a few cases of NXG without paraproteinemia (isolated NXG) have also been reported. Main observation: A 58-year-old Japanese woman complained about asymptomatic dermal nodules on the bilateral lower eyelids. The histopathological examination revealed granulomatous inflammation. Paraproteinemia was not detected either in the serum or in the urine. The size of the nodules has been constant, and she has been under careful follow-up without any systemic therapies. Conclusions: NXG is frequently associated with paraproteinemia, which may develop later. Patients with NXG need careful follow-up including repeated blood tests.
AbstractList Introduction: Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disease which most frequently involves periorbital areas. NXG is associated with paraproteinemia with a ratio over 80%. However, a few cases of NXG without paraproteinemia (isolated NXG) have also been reported. Main observation: A 58-year-old Japanese woman complained about asymptomatic dermal nodules on the bilateral lower eyelids. The histopathological examination revealed granulomatous inflammation. Paraproteinemia was not detected either in the serum or in the urine. The size of the nodules has been constant, and she has been under careful follow-up without any systemic therapies. Conclusions: NXG is frequently associated with paraproteinemia, which may develop later. Patients with NXG need careful follow-up including repeated blood tests.
Author Nakamura-Wakatsuki, Taeko
Yamamoto, Toshiyuki
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Snippet Introduction: Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disease which most frequently involves periorbital areas. NXG is associated with...
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SubjectTerms Case reports
Collagen
Disease
Immunoglobulins
Inflammation
Laboratories
Lymphocytes
Lymphoma
Multiple myeloma
necrobiotic xanthogranuloma
no paraproteinemia
Pathogenesis
periorbital lesions
Proteins
Skin
Tomography
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