Associations between IL-17A G/A-rs2275913 and IL 23R A/G-rs11209026 gene polymorphisms and severe coronavirus disease 2019 (COVID-19)

• Published in: The Egyptian journal of immunology Vol. 30; no. 2; p. 119
• Main Authors: Goda, Asmaa M, Abdelrahman, Mona M, Fattouh, Mona, Hemdan, Shimaa B, Abdel Baset, Asmaa A, Younis, Mustafa A, Abuzied, Enas K A, Mahmoud, Mahmoud G, Shafik, Noha S
• Format: Journal Article
• Language: English
• Published: Egypt 01.04.2023
• Subjects: Case-Control Studies; COVID-19 - genetics; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-17 - genetics; Interleukin-23 - genetics; Polymorphism, Single Nucleotide; SARS-CoV-2

Severe COVID-19 disease was linked to a severe proinflammatory response and cytokine storm interleukin 17 (IL-17) is one of these cytokines, was associated with severe acute lung injury and multiorgan dysfunction. Single nucleotide polymorphisms (SNPs) in genes coding IL-17 can affect level of IL-17...