Efficacy and Safety of Alteplase Combined with Urinarykallid for Intravenous Thrombolysis on Acute Cerebral Infarction
This study aimed to explore the efficacy and safety of alteplase combined with urinarykallid for the intravenous thrombolysis of patients with acute cerebral infarction. Patients ( n = 125) who were admitted to our hospital were included and divided into Group A ( n = 60) and Group B ( n = 65). Pati...
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| Published in | Neurochemical journal Vol. 18; no. 1; pp. 226 - 232 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Pleiades Publishing
01.03.2024
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| Abstract | This study aimed to explore the efficacy and safety of alteplase combined with urinarykallid for the intravenous thrombolysis of patients with acute cerebral infarction. Patients (
n
= 125) who were admitted to our hospital were included and divided into Group A (
n
= 60) and Group B (
n
= 65). Patients in Group A were treated with alteplase for intravenous thrombolysis, based on which urinarykallid was administered to patients in Group B as a combination treatment. Compared to Group A, Group B was significantly lower in hs-CRP and TNF-α levels (
p
< 0.001), total incidence of adverse reactions (
p
< 0.05), and NIHSS score (
p
< 0.001) and higher in IL-10 level (
p
< 0.001), total effective rate (markedly effective + effective/total cases × 100%. Compared to the single administration of alteplase, the combination of alteplase and urinarykallid for the intravenous thrombolysis of patients with acute cerebral infarction can achieve better efficacy at a lower incidence of adverse reactions and play a more significant role in clinical treatment. |
|---|---|
| AbstractList | This study aimed to explore the efficacy and safety of alteplase combined with urinarykallid for the intravenous thrombolysis of patients with acute cerebral infarction. Patients (
n
= 125) who were admitted to our hospital were included and divided into Group A (
n
= 60) and Group B (
n
= 65). Patients in Group A were treated with alteplase for intravenous thrombolysis, based on which urinarykallid was administered to patients in Group B as a combination treatment. Compared to Group A, Group B was significantly lower in hs-CRP and TNF-α levels (
p
< 0.001), total incidence of adverse reactions (
p
< 0.05), and NIHSS score (
p
< 0.001) and higher in IL-10 level (
p
< 0.001), total effective rate (markedly effective + effective/total cases × 100%. Compared to the single administration of alteplase, the combination of alteplase and urinarykallid for the intravenous thrombolysis of patients with acute cerebral infarction can achieve better efficacy at a lower incidence of adverse reactions and play a more significant role in clinical treatment. |
| Author | Bao, Linyi Jin, Haimiao Chen, Yun Jiahui Shao Jin, Xinchun |
| Author_xml | – sequence: 1 surname: Jiahui Shao fullname: Jiahui Shao organization: Department of Neurology, The First People’s Hospital of Wenling – sequence: 2 givenname: Linyi surname: Bao fullname: Bao, Linyi organization: Department of Neurology, The First People’s Hospital of Wenling – sequence: 3 givenname: Xinchun surname: Jin fullname: Jin, Xinchun organization: Department of Neurology, The First People’s Hospital of Wenling – sequence: 4 givenname: Haimiao surname: Jin fullname: Jin, Haimiao organization: Department of Neurology, The First People’s Hospital of Wenling – sequence: 5 givenname: Yun surname: Chen fullname: Chen, Yun email: chenyun8521@126.com organization: Department of Neurology, Taizhou Central Hospital |
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| Cites_doi | 10.1371/journal.pone.0134543 10.1161/01.STR.0000258112.14918.24 10.1038/jcbfm.2010.19 10.2165/00003495-199550010-00008 10.1016/S0140-6736(98)03454-0 10.1056/NEJMoa0804656 10.1016/S0140-6736(98)08020-9 10.1016/j.jstrokecerebrovasdis.2017.06.012 10.1056/NEJMoa1414905 10.1056/NEJMoa1411587 10.1016/j.apsb.2016.06.013 10.1007/s12035-015-9226-y 10.1016/S0140-6736(04)15692-4 10.1212/WNL.55.11.1649 10.1089/hum.2006.17.206 10.1097/00005650-199206000-00002 10.1111/j.1756-5391.2012.01167.x 10.1179/016164110X12656393665206 10.1113/expphysiol.2004.028464 10.1155/MI/2006/65237 10.3988/jcn.2017.13.1.1 |
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| Copyright | Pleiades Publishing, Ltd. 2024. ISSN 1819-7124, Neurochemical Journal, 2024, Vol. 18, No. 1, pp. 226–232. © Pleiades Publishing, Ltd., 2024. |
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| References | HackeW.KasteM.FieschiC.von KummerR.DavalosA.MeierD.LarrueV.BluhmkiE.DavisS.DonnanG.SchneiderD.Diez-TejedorE.TrouillasP.Lancet1998352124512511:CAS:528:DyaK1cXnt1egtLo%3D10.1016/S0140-6736(98)08020-99788453 ZhangJ.B.DingZ.Y.YangY.SunW.HaiF.SuiX.N.LiX.Y.WangH.Z.WangX.T.ZhengJ.L.Neurol. Res.20103235335810.1179/016164110X1265639366520620483000 XiaC.-F.YinH.YaoY.-Y.BorlonganC.V.ChaoL.,ChaoJ.Hum. Gene Ther.2006172062191:CAS:528:DC%2BD28XpvV2hsg%3D%3D10.1089/hum.2006.17.20616454654 ChenZ.B.HuangD.Q.NiuF.N.ZhangX.LiE.G.,XuY.J. Cereb. Blood Flow Metab.201030135613651:CAS:528:DC%2BC3cXotlSlu7s%3D10.1038/jcbfm.2010.19201797262949229 OnoH.NishijimaY.OhtaS.SakamotoM.KinoneK.HorikosiT.TamakiM.TakeshitaH.FutatukiT.OhishiW.IshiguroT.OkamotoS.IshiiS.TakanamiH.J. Stroke Cerebrovasc. Dis.2017262587259410.1016/j.jstrokecerebrovasdis.2017.06.01228669654 HackeW.KasteM.BluhmkiE.BrozmanM.DávalosA.GuidettiD.LarrueV.LeesK.R.MedeghriZ.MachnigT.N. Engl. J. Med.2008359131713291:CAS:528:DC%2BD1cXhtFGqu77E10.1056/NEJMoa080465618815396 CollaborativeE.S.C.H.D.Lancet19983521801180710.1016/S0140-6736(98)03454-0 ChaoJ.ChaoL.Exp. Physiol.2005902912981:CAS:528:DC%2BD2MXltVWrsrc%3D10.1113/expphysiol.2004.02846415653716 GoyalM.DemchukA.M.MenonB.K.EesaM.RempelJ.L.ThorntonJ.RoyD.JovinT.G.WillinskyR.A.,SapkotaB.L.N. Engl. J. Med.2015372101910301:CAS:528:DC%2BC2MXkvV2kt7w%3D10.1056/NEJMoa141490525671798 ATLANTIS, T., Lancet, 2004, vol. 363, no. 9411, pp. 768–774. ZhangC.TaoW.LiuM.WangD.J. Evid. Based Med.20125313910.1111/j.1756-5391.2012.01167.x23528118 MarlerJ.R.TilleyB.LuM.BrottT.G.LydenP.GrottaJ.BroderickJ.LevineS.FrankelM.,HorowitzS.Neurology200055164916551:STN:280:DC%2BD3M%2FnvFSrtA%3D%3D10.1212/WNL.55.11.164911113218 HillM.D.BarberP.A.TakahashiJ.DemchukA.M.FeasbyT.E.,BuchanA.M.CMAJ2000162128112841:STN:280:DC%2BD3c3nt1yrug%3D%3D108130081232409 Mahoney, F.I. and Barthel, D.W., Md. State Med. J., 1965. Ortiz, G.A. and L. Sacco, R., Wiley Stats. Ref.: Statistics Reference Online, 2014. WuW.GuanY.XuK.FuX.-J.LeiX.-F.LeiL.-J.ZhangZ.-Q.ChengY.LiY.-Q.Mol. Neurobiol.201653251025171:CAS:528:DC%2BC2MXhtVartb7I10.1007/s12035-015-9226-y26063590 GillisJ.C.WagstaffA.J.GoaK.L.Drugs1995501021361:STN:280:DyaK28%2FnvValsA%3D%3D10.2165/00003495-199550010-000087588083 SongX.HanL.LiuY.Neural Regen. Res201278678731:CAS:528:DC%2BC38XhtFOit7rF257377164342716 VidaleS.ConsoliA.ArnaboldiM.ConsoliD.J. Clin. Neurol.2017131910.3988/jcn.2017.13.1.128079313 ZhaoF.YuanF.Chinese Journal of Practical Medicine201845116118 BerkhemerO.A.FransenP.S.BeumerD.van den BergL.A.LingsmaH.F.YooA.J.SchonewilleW.J.VosJ.A.NederkoornP.J.,WermerM.J.N. Engl. J. Med.2015372112010.1056/NEJMoa141158725517348 FrameworkI.C.Med. Care1992304738310.1097/00005650-199206000-00002 MartinK.VieraK.PetrC.MarieN.EvaT.Mediators Inflamm.200620066523710.1155/MI/2006/65237173925761657080 HanL.LiJ.ChenY.ZhangM.QianL.ChenY.WuZ.XuY.LiJ.PLoS One201510e013454310.1371/journal.pone.0134543262220554519127 RhaJ.-H.SaverJ.L.Stroke20073896797310.1161/01.STR.0000258112.14918.2417272772 ChenX.WangK.Acta Pharm. Sin. B2016652253010.1016/j.apsb.2016.06.013278189185071630 H. Ono (5315_CR13) 2017; 26 J.B. Zhang (5315_CR9) 2010; 32 J.C. Gillis (5315_CR19) 1995; 50 S. Vidale (5315_CR3) 2017; 13 Z.B. Chen (5315_CR12) 2010; 30 C. Zhang (5315_CR26) 2012; 5 K. Martin (5315_CR14) 2006; 2006 L. Han (5315_CR23) 2015; 10 F. Zhao (5315_CR27) 2018; 45 5315_CR16 Z.B. Chen (5315_CR24) 2010; 30 5315_CR15 W. Hacke (5315_CR8) 1998; 352 J.-H. Rha (5315_CR6) 2007; 38 C.-F. Xia (5315_CR22) 2006; 17 O.A. Berkhemer (5315_CR2) 2015; 372 M. Goyal (5315_CR5) 2015; 372 I.C. Framework (5315_CR17) 1992; 30 W. Wu (5315_CR18) 2016; 53 5315_CR20 J. Chao (5315_CR10) 2005; 90 E.S.C.H.D. Collaborative (5315_CR1) 1998; 352 J.R. Marler (5315_CR21) 2000; 55 X. Song (5315_CR11) 2012; 7 X. Chen (5315_CR4) 2016; 6 W. Hacke (5315_CR7) 2008; 359 M.D. Hill (5315_CR25) 2000; 162 |
| References_xml | – reference: HackeW.KasteM.FieschiC.von KummerR.DavalosA.MeierD.LarrueV.BluhmkiE.DavisS.DonnanG.SchneiderD.Diez-TejedorE.TrouillasP.Lancet1998352124512511:CAS:528:DyaK1cXnt1egtLo%3D10.1016/S0140-6736(98)08020-99788453 – reference: HackeW.KasteM.BluhmkiE.BrozmanM.DávalosA.GuidettiD.LarrueV.LeesK.R.MedeghriZ.MachnigT.N. Engl. J. Med.2008359131713291:CAS:528:DC%2BD1cXhtFGqu77E10.1056/NEJMoa080465618815396 – reference: OnoH.NishijimaY.OhtaS.SakamotoM.KinoneK.HorikosiT.TamakiM.TakeshitaH.FutatukiT.OhishiW.IshiguroT.OkamotoS.IshiiS.TakanamiH.J. Stroke Cerebrovasc. Dis.2017262587259410.1016/j.jstrokecerebrovasdis.2017.06.01228669654 – reference: MarlerJ.R.TilleyB.LuM.BrottT.G.LydenP.GrottaJ.BroderickJ.LevineS.FrankelM.,HorowitzS.Neurology200055164916551:STN:280:DC%2BD3M%2FnvFSrtA%3D%3D10.1212/WNL.55.11.164911113218 – reference: HanL.LiJ.ChenY.ZhangM.QianL.ChenY.WuZ.XuY.LiJ.PLoS One201510e013454310.1371/journal.pone.0134543262220554519127 – reference: ZhaoF.YuanF.Chinese Journal of Practical Medicine201845116118 – reference: HillM.D.BarberP.A.TakahashiJ.DemchukA.M.FeasbyT.E.,BuchanA.M.CMAJ2000162128112841:STN:280:DC%2BD3c3nt1yrug%3D%3D108130081232409 – reference: Mahoney, F.I. and Barthel, D.W., Md. State Med. J., 1965. – reference: FrameworkI.C.Med. Care1992304738310.1097/00005650-199206000-00002 – reference: MartinK.VieraK.PetrC.MarieN.EvaT.Mediators Inflamm.200620066523710.1155/MI/2006/65237173925761657080 – reference: SongX.HanL.LiuY.Neural Regen. Res201278678731:CAS:528:DC%2BC38XhtFOit7rF257377164342716 – reference: XiaC.-F.YinH.YaoY.-Y.BorlonganC.V.ChaoL.,ChaoJ.Hum. Gene Ther.2006172062191:CAS:528:DC%2BD28XpvV2hsg%3D%3D10.1089/hum.2006.17.20616454654 – reference: RhaJ.-H.SaverJ.L.Stroke20073896797310.1161/01.STR.0000258112.14918.2417272772 – reference: ZhangC.TaoW.LiuM.WangD.J. Evid. Based Med.20125313910.1111/j.1756-5391.2012.01167.x23528118 – reference: ATLANTIS, T., Lancet, 2004, vol. 363, no. 9411, pp. 768–774. – reference: GoyalM.DemchukA.M.MenonB.K.EesaM.RempelJ.L.ThorntonJ.RoyD.JovinT.G.WillinskyR.A.,SapkotaB.L.N. Engl. J. Med.2015372101910301:CAS:528:DC%2BC2MXkvV2kt7w%3D10.1056/NEJMoa141490525671798 – reference: Ortiz, G.A. and L. Sacco, R., Wiley Stats. Ref.: Statistics Reference Online, 2014. – reference: CollaborativeE.S.C.H.D.Lancet19983521801180710.1016/S0140-6736(98)03454-0 – reference: ZhangJ.B.DingZ.Y.YangY.SunW.HaiF.SuiX.N.LiX.Y.WangH.Z.WangX.T.ZhengJ.L.Neurol. Res.20103235335810.1179/016164110X1265639366520620483000 – reference: ChaoJ.ChaoL.Exp. Physiol.2005902912981:CAS:528:DC%2BD2MXltVWrsrc%3D10.1113/expphysiol.2004.02846415653716 – reference: WuW.GuanY.XuK.FuX.-J.LeiX.-F.LeiL.-J.ZhangZ.-Q.ChengY.LiY.-Q.Mol. Neurobiol.201653251025171:CAS:528:DC%2BC2MXhtVartb7I10.1007/s12035-015-9226-y26063590 – reference: ChenZ.B.HuangD.Q.NiuF.N.ZhangX.LiE.G.,XuY.J. Cereb. Blood Flow Metab.201030135613651:CAS:528:DC%2BC3cXotlSlu7s%3D10.1038/jcbfm.2010.19201797262949229 – reference: GillisJ.C.WagstaffA.J.GoaK.L.Drugs1995501021361:STN:280:DyaK28%2FnvValsA%3D%3D10.2165/00003495-199550010-000087588083 – reference: ChenX.WangK.Acta Pharm. Sin. B2016652253010.1016/j.apsb.2016.06.013278189185071630 – reference: BerkhemerO.A.FransenP.S.BeumerD.van den BergL.A.LingsmaH.F.YooA.J.SchonewilleW.J.VosJ.A.NederkoornP.J.,WermerM.J.N. Engl. J. Med.2015372112010.1056/NEJMoa141158725517348 – reference: VidaleS.ConsoliA.ArnaboldiM.ConsoliD.J. Clin. Neurol.2017131910.3988/jcn.2017.13.1.128079313 – volume: 10 start-page: e0134543 year: 2015 ident: 5315_CR23 publication-title: PLoS One doi: 10.1371/journal.pone.0134543 – volume: 38 start-page: 967 year: 2007 ident: 5315_CR6 publication-title: Stroke doi: 10.1161/01.STR.0000258112.14918.24 – volume: 30 start-page: 1356 year: 2010 ident: 5315_CR12 publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2010.19 – volume: 50 start-page: 102 year: 1995 ident: 5315_CR19 publication-title: Drugs doi: 10.2165/00003495-199550010-00008 – volume: 352 start-page: 1801 year: 1998 ident: 5315_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(98)03454-0 – volume: 45 start-page: 116 year: 2018 ident: 5315_CR27 publication-title: Chinese Journal of Practical Medicine – volume: 359 start-page: 1317 year: 2008 ident: 5315_CR7 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0804656 – volume: 352 start-page: 1245 year: 1998 ident: 5315_CR8 publication-title: Lancet doi: 10.1016/S0140-6736(98)08020-9 – volume: 26 start-page: 2587 year: 2017 ident: 5315_CR13 publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.012 – volume: 372 start-page: 1019 year: 2015 ident: 5315_CR5 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1414905 – volume: 372 start-page: 11 year: 2015 ident: 5315_CR2 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1411587 – volume: 6 start-page: 522 year: 2016 ident: 5315_CR4 publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2016.06.013 – ident: 5315_CR15 – volume: 53 start-page: 2510 year: 2016 ident: 5315_CR18 publication-title: Mol. Neurobiol. doi: 10.1007/s12035-015-9226-y – ident: 5315_CR20 doi: 10.1016/S0140-6736(04)15692-4 – volume: 162 start-page: 1281 year: 2000 ident: 5315_CR25 publication-title: CMAJ – volume: 55 start-page: 1649 year: 2000 ident: 5315_CR21 publication-title: Neurology doi: 10.1212/WNL.55.11.1649 – volume: 7 start-page: 867 year: 2012 ident: 5315_CR11 publication-title: Neural Regen. Res – volume: 17 start-page: 206 year: 2006 ident: 5315_CR22 publication-title: Hum. Gene Ther. doi: 10.1089/hum.2006.17.206 – volume: 30 start-page: 473 year: 1992 ident: 5315_CR17 publication-title: Med. Care doi: 10.1097/00005650-199206000-00002 – volume: 5 start-page: 31 year: 2012 ident: 5315_CR26 publication-title: J. Evid. Based Med. doi: 10.1111/j.1756-5391.2012.01167.x – volume: 32 start-page: 353 year: 2010 ident: 5315_CR9 publication-title: Neurol. Res. doi: 10.1179/016164110X12656393665206 – volume: 90 start-page: 291 year: 2005 ident: 5315_CR10 publication-title: Exp. Physiol. doi: 10.1113/expphysiol.2004.028464 – volume: 2006 start-page: 65237 year: 2006 ident: 5315_CR14 publication-title: Mediators Inflamm. doi: 10.1155/MI/2006/65237 – volume: 30 start-page: 1356 year: 2010 ident: 5315_CR24 publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2010.19 – volume: 13 start-page: 1 year: 2017 ident: 5315_CR3 publication-title: J. Clin. Neurol. doi: 10.3988/jcn.2017.13.1.1 – ident: 5315_CR16 |
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| Title | Efficacy and Safety of Alteplase Combined with Urinarykallid for Intravenous Thrombolysis on Acute Cerebral Infarction |
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