INDENO[1,2,3-DE]PHTHALAZIN-3(2H)-ONE AND ITS ANALOGS – SYNTHESIS AND ANTIINFLAMMATORY PROPERTIES

• Published in: Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ Vol. 21; no. 1(57); pp. 59 - 71
• Main Authors: Bondar, K. V., Klimenko, K. О., Alexandrova, О. І., Kravchenko, І. А., Schepetkin, I. A., Lyakhov, S. А.
• Format: Journal Article
• Language: English
• Published: Odessa I. I. Mechnikov National University 26.04.2016
• Subjects: афінітет; докінг; запалення; карагінан; кінази; набряк; прозапальні цитокіни; синтез; щури; інденофталазін

The purpose of this work was design planar polycyclic compounds as inhibitors of kinases, involved in the pro-inflammatory cascade. These compounds can be used as potential hits for the further anti-inflammatory drug design. Dibenzo[cd,g]indazol-6(2H)-one (1) has been shown as a competitive JNK inhi...