Pd-0-Catalyzed Intramolecular alpha-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines
A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd-0-catalyzed intramolecular -arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processe...
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| Published in | Chemistry : a European journal Vol. 21; no. 12; pp. 4580 - 4584 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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WEINHEIM
Wiley
16.03.2015
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| Abstract | A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd-0-catalyzed intramolecular -arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. |
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| AbstractList | Abstract
A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd
0
‐catalyzed intramolecular α‐arylation of sulfones is reported. The combination of this Pd‐catalyzed reaction with intermolecular Michael and aza‐Michael reactions allows the development of two‐ and three‐step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd-0-catalyzed intramolecular -arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. |
| Author | Sole, Daniel Perez-Janer, Ferran Mancuso, Raffaella |
| Author_xml | – sequence: 1 givenname: Daniel surname: Sole fullname: Sole, Daniel email: dsole@ub.edu organization: Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain – sequence: 2 givenname: Ferran surname: Perez-Janer fullname: Perez-Janer, Ferran organization: Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain – sequence: 3 givenname: Raffaella surname: Mancuso fullname: Mancuso, Raffaella organization: Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain |
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| CitedBy_id | crossref_primary_10_1002_chin_201532174 crossref_primary_10_3390_catal8100458 crossref_primary_10_1021_acs_joc_8b00287 crossref_primary_10_1002_ajoc_202200440 crossref_primary_10_1002_anie_201602020 crossref_primary_10_1002_ange_201602020 crossref_primary_10_1021_acs_joc_6b00341 crossref_primary_10_1002_ejoc_201601300 crossref_primary_10_1016_j_tet_2019_02_041 crossref_primary_10_3390_molecules24193551 crossref_primary_10_1039_D3NJ04668K crossref_primary_10_1055_a_2282_7702 crossref_primary_10_1002_chem_201902104 crossref_primary_10_1021_acscatal_6b00027 |
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| Keywords | AZA-MICHAEL ADDITION ISOQUINOLINE ALKALOIDS arylation sulfones domino reactions CYCLIZATION REACTIONS nitrogen heterocycles ARYL HALIDES ESTERS palladium ENOLATE ARYLATION DERIVATIVES TETHERED VINYL HALIDES PD-CATALYZED REACTIONS CATALYZED DIRECT ARYLATION |
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| Snippet | A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd-0-catalyzed intramolecular -arylation of sulfones is reported. The combination of... Abstract A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd 0 ‐catalyzed intramolecular α‐arylation of sulfones is reported. The... |
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| Title | Pd-0-Catalyzed Intramolecular alpha-Arylation of Sulfones: Domino Reactions in the Synthesis of Functionalized Tetrahydroisoquinolines |
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