Correction of neurovegetative and psychoemotional disorders in patients with post-castration syndrome by non-drug means

• Published in: Voprosy kurortologii, fizioterapii i lečebnoj fizičeskoj kulʹtury Vol. 98; no. 2; p. 24
• Main Authors: Gridneva, T D, Perminova, E V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2021
• Subjects: Anxiety - therapy; Anxiety Disorders; Castration; Humans; Quality of Life; Syndrome; post-castration syndrome; sanatorium rehabilitation; gynecological oncology
• ISSN: 0042-8787
• DOI: 10.17116/kurort20219802124

Due to decrease in life quality of gynecological oncology patients after completed radical antitumor treatment because of chemotherapy and radiation therapy consequences, pre- and postoperative stress, the development of post-castration syndrome, the problem of this contingent rehabilitation remains important. The methods of non-drug therapy, in particular, physical factors that have a multifaceted effect on the body and increase its resistance to adverse conditions are of interest. These factors include normobaric hypoxia which improves oxygen transport and tissue respiration, enhances detoxification processes, increases mental and physical performance, and increases the body's nonspecific resistance. EHF-therapy promotes the implementation of anti-stress reactions, normalizes the activity of the sympathoadrenal link of the autonomic nervous system. It is assumed that the complex use of normobaric hypoxia and EHF-therapy would reduce the negative consequences of antitumor treatment and lead to positive dynamics of the post-castration syndrome clinical picture. To study the dynamics of neurovegetative and psychoemotional disorders during rehabilitation in patients with post-castration syndrome after completed radical antitumor treatment for cervical cancer or uterine body cancer Ib-IIb stages. 106 patients with post-castration syndrome developed after radical antitumor treatment for cervical cancer or uterine body cancer stage Ib-IIb were examined. The main group consisted of 66 patients who received the author's rehabilitation program which included normobaric hypoxia procedures, EHF-therapy and water aerobics 6-12 months after the completed radical antitumor treatment. The control group consisted of 40 patients were examined according to the protocol at the same time but they were not assigned a course of rehabilitation. After the completed radical antitumor treatment (6-12 months) the neurovegetative and psychoemotional disorders including anxiety and depression persisted. After patients' rehabilitation the severity of clinical symptoms of post-castration syndrome decreased; that was accompanied by positive dynamics of neurovegetative ( <0.01) and psychoemotional ( <0.01) symptoms (Kupperman scale), indicators of anxiety ( <0.01) and depression ( <0.05) (HADS scale), situational anxiety ( <0.01) (Spielberger-Khanin scale), the severity of mental and somatic signs of anxiety by 51.0% (Hamilton scale). The proposed rehabilitation complex helps to reduce the functional tension of the higher nervous system autonomic centers and to increase the nonspecific body reactivity. This allows to recommend the proposed course for the rehabilitation of this patients' category.