Antiproliferative Effect of Viscum album Alcoholic Extract In vitro

• Published in: Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine Vol. 72; no. 1; pp. 170 - 173
• Main Authors: Sarpataki, Orsolya, Pall, Emöke, Sevastre-Berghian, Alexandra C, Stan, Roxana L, Hanganu, Daniela, Benedec, Daniela, Hangan, Adriana C, Sevastre, Bogdan, Marcus, Ioan
• Format: Journal Article
• Language: English
• Published: 29.05.2015
• Subjects: Viscum; Viscum album
• ISSN: 1843-5270; 1843-5378
• DOI: 10.15835/buasvmcn-vm:11108

Viscum album(VA), is a hemi-parasitic plant that grows on various trees. VA has a long tradition as medicinal plant, being used in traditional medicine. Recently, many in vitro and in vivo experimental studies investigate the antitumor properties of VA extracts. The assessment of antiproliferative effect was performed both on normal human fibroblasts (Hfl) and on a tumor cell line (Hela). The cell cytotoxicity assay was performed using the MTT test as specified by the manufacturer. Cell viability is gradually reduced in HeLa tumor cells line from 44.58% at 5 mu g/ml VA extract, to 9.35% at the dose of 50 mu g / ml. HFL cells are not affected in the same manner by the extract, 63.65% of these cells are viable at 50 mu g / ml, the highest dose tested. In conclusion, VA provides a significant, selective antitumor effect on cell culture models