YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis

AbstractYM-216391, a novel cytotoxic cyclic peptide, has been isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. The planar structure of YM-216391 was assigned on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of the amino acid residues in YM-21639...

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Published inJournal of antibiotics Vol. 58; no. 1; p. 32
Main Authors Sohda, Kin-ya, Hiramoto, Masashi, Suzumura, Ken-ichi, Takebayashi, Yukihiro, Suzuki, Ken-ichi, Tanaka, Akihiro
Format Journal Article
LanguageEnglish
Published Tokyo Nature Publishing Group 01.01.2005
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Summary:AbstractYM-216391, a novel cytotoxic cyclic peptide, has been isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. The planar structure of YM-216391 was assigned on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of the amino acid residues in YM-216391 was determined by Marfey's analysis and chiral HPLC analysis of its acid hydrolysate.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2005.3