Safety and immunogenicity of IMVAMUNE®, a third-generation vaccine based on the modified vaccinia Ankara (MVA) strain

• Published in: Biopreparaty Vol. 23; no. 1; pp. 26 - 41
• Main Authors: Stovba, L. F., Chukhralya, O. V., Chernikova, N. K., Khmelev, A. L., Borisevich, S. V.
• Format: Magazine Article
• Language: English; Russian
• Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products 01.04.2023
• Subjects: geometric mean antibody titers; monkeypox; orthopoxviruses; priming/boosting; seroconversion rate; third-generation smallpox vaccine; vaccination; vaccinia virus

In 1980, the World Health Assembly officially declared smallpox eradicated in the world, which allowed developed countries to stop preventive vaccination against this disease. However, circulating and emerging orthopoxviruses along with the lack of herd immunity prompt the need for emergency smallpo...