Spatial Pattern of Medial Temporal Lobe Cross‐Sectional and Longitudinal Structural Change in Cognitively Normal Individuals

• Published in: Alzheimer's & dementia Vol. 20; no. S2
• Main Authors: Xie, Long, Das, Sandhitsu R., Li, Yue, Wisse, Laura E.M., McGrew, Emily, Lyu, Xueying, DiCalogero, Michael, Shah, Ujashi, Ilesanmi, Ademola, Denning, Amanda E, Brown, Christopher D., Cohen, Jesse S, Sreepada, Lasya P, Dong, Mengjin, Sadeghpour, Niyousha, Khandelwal, Pulkit, Ittyerah, Ranjit, Ravikumar, Sadhana, Sadaghiani, Shokufeh, Hrybouski, Stanislau, de Flores, Robin, Gibson, Eli, Yushkevich, Paul A., Wolk, David A
• Format: Journal Article
• Language: English
• Published: Hoboken John Wiley and Sons Inc 01.12.2024
• Subjects: Biomarkers

Background The medial temporal lobe's (MTL) early involvement in tau pathology makes it a key focus in the development of preclinical Alzheimer’s disease (AD) biomarkers. ROI analyses in prior studies reported significant MTL structural differences in cognitively normal individuals with and wit...