False estimates of elevated creatinine

One of the most common reasons for a nephrology consult is an elevated creatinine. An elevation in the serum creatinine concentration usually reflects a reduction in the glomerular filtration rate (GFR). Given the association of elevated creatinine and risk of cardiovascular mortality, it is importa...

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Bibliographic Details
Published inPermanente journal Vol. 16; no. 2; p. 51
Main Authors Samra, Manpreet, Abcar, Antoine C
Format Journal Article
LanguageEnglish
Published United States 2012
Subjects
Creatinine - blood
Diagnosis, Differential
Female
Fenofibrate - adverse effects
Glomerular Filtration Rate
Humans
Hyperlipidemias - drug therapy
Hypolipidemic Agents - adverse effects
Kidney - physiopathology
Kidney Diseases - diagnosis
Middle Aged
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Summary:One of the most common reasons for a nephrology consult is an elevated creatinine. An elevation in the serum creatinine concentration usually reflects a reduction in the glomerular filtration rate (GFR). Given the association of elevated creatinine and risk of cardiovascular mortality, it is important to keep in mind that at times the elevation of the creatinine is not representative of a true reduction in GFR. There are various causes of factitious elevation of creatinine. They can be broadly grouped into increased production of creatinine, interference with the assay and decreased tubular secretion of creatinine.
ISSN:1552-5775
1552-5775
DOI:10.7812/TPP/12.985