IL-5Rα expression on airway neutrophils in children with treatment-refractory asthma

Rationale Asthma is a chronic inflammatory lung disorder affecting 9% of children in the United States, a subset of whom have treatment-resistant disease and experience significant morbidity. Methods Children with treatment-refractory asthma (n=48) underwent diagnostic bronchoscopy and collection of...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 141; no. 2; p. AB284
Main Authors Lawrence, Monica G., Spano, MarthaJoy M., Hinkelman, Amy, Steinke, John W., Borish, Larry, Braciale, Thomas J., Teague, W. Gerald
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2018
Elsevier Limited
Subjects
Asthma
Children
Leukocytes (neutrophilic)
Morbidity
Neutrophils
Respiratory tract
United States > US
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Summary:Rationale Asthma is a chronic inflammatory lung disorder affecting 9% of children in the United States, a subset of whom have treatment-resistant disease and experience significant morbidity. Methods Children with treatment-refractory asthma (n=48) underwent diagnostic bronchoscopy and collection of bronchoalveolar lavage fluid (BALF).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.904