β 2 -Adrenergic Stimulation Compartmentalizes β 1 Signaling Into Nanoscale Local Domains by Targeting the C-Terminus of β 1 -Adrenoceptors

βARs (β-adrenergic receptors) are prototypical GPCRs (G protein-coupled receptors) that play a pivotal role in sympathetic regulation. In heart cells, β AR signaling mediates a global response, including both l-type Ca channels in the sarcolemma/T tubules and RyRs (ryanodine receptors) in the SR (sa...

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Bibliographic Details
Published inCirculation research Vol. 124; no. 9; pp. 1350 - 1359
Main Authors Yang, Hua-Qian, Wang, Li-Peng, Gong, Yun-Yun, Fan, Xue-Xin, Zhu, Si-Yu, Wang, Xiao-Ting, Wang, Yu-Pu, Li, Lin-Lin, Xing, Xin, Liu, Xiao-Xiao, Ji, Guang-Shen, Hou, TingTing, Zhang, Yan, Xiao, Rui-Ping, Wang, Shi-Qiang
Format Journal Article
LanguageEnglish
Published United States 26.04.2019
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