Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-β Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study1

• Published in: Journal of Alzheimer's disease Vol. 77; no. 1; p. 99
• Main Authors: Rejc, Luka, Gómez-Vallejo, Vanessa, Rios, Xabier, Cossío, Unai, Baz, Zuriñe, Mujica, Edurne, Gião, Tiago, Cotrina, Ellen Y, Jiménez-Barbero, Jesús, Quintana, Jordi, Arsequell, Gemma, Cardoso, Isabel, Llop, Jordi
• Format: Journal Article
• Language: English
• Published: Netherlands 2020
• Subjects: TTR/Aβ interaction; disease-modifying drug; Alzheimer’s disease; positron emission tomography; transthyretin; small-molecule chaperones

Transthyretin (TTR) is a tetrameric, amyloid-β (Aβ)-binding protein, which reduces Aβ toxicity. The TTR/Aβ interaction can be enhanced by a series of small molecules that stabilize its tetrameric form. Hence, TTR stabilizers might act as disease-modifying drugs in Alzheimer's disease. We monito...