Targeted Discovery and Characterization of Type‐II PKS‐NRPS Hybrid DNA‐Alkylating Antibiotics

• Published in: Angewandte Chemie International Edition p. e202512820
• Main Authors: Nie, Qiu‐Yue, Fang, Shi‐Qi, Wu, Lian, Gao, Ruo‐Qin, Hu, Yu, Ding, Dian, Pan, Hai‐Xue, Pei, Zeng‐Fei, He, Jun‐Bin, Zhou, Qiang, Chen, Zi‐Hui, Hou, Xian‐Feng, Zhao, Xin‐Qing, Tang, Gong‐Li
• Format: Journal Article
• Language: English
• Published: Germany 05.08.2025
• Subjects: Self‐resistance; Natural product discovery; Xinghaicarcin; PKS‐II‐NRPS; DNA‐alkylating antibiotics

DNA alkylating natural products usually exhibit diverse bioactivity and serve as a crucial source of drug leads. Here, we employed genome mining guided by HTH‐42 superfamily resistance gene to precisely discover a new class of DNA‐alkylating antibiotics, xinghaicarcins, from Streptomyces xinghaiensi...