Genetic testing for childhood cancer predisposition syndromes: Controversies and recommendations from the SIOPE Host Genome Working Group meeting 2022
Cancer Predisposition Syndromes (CPSs) have been identified in 7–15 % of children with cancer. The possibilities for germline genetic testing have increased in recent years, presenting new opportunities but also challenges. There is currently no consensus on germline genetic testing in children with...
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Published in | EJC paediatric oncology Vol. 4; p. 100176 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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01.12.2024
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Abstract | Cancer Predisposition Syndromes (CPSs) have been identified in 7–15 % of children with cancer. The possibilities for germline genetic testing have increased in recent years, presenting new opportunities but also challenges. There is currently no consensus on germline genetic testing in children with cancer in diagnostic settings.
The International Society of Pediatric Oncology Europe (SIOPE) Host Genome Working Group used a consensus development conference method to reach agreement on four key topics: Who do we test? Which genes do we test? What do we disclose? How do we evaluate the benefits of testing?
The Working Group members agreed that: (1) All children with cancer should undergo clinical screening for their risk of harboring a CPS. (2) Targeted genetic testing based on clinical indication is recommended. Comprehensive CPS gene panels with more than 100–150 genes for all children with cancer should preferably be evaluated within research settings. (3) Smaller actionable gene panels can be considered including genes supporting diagnosis or influencing treatment decisions. (4) Clear pre-test information and consenting processes that highlight potential outcomes and implications of germline genetic testing are imperative. (5) Consequences of genetic testing, treatment adaption, and tumor surveillance in children with CPSs, including economic impact and psychosocial factors, should be further explored.
These consensus-based recommendations provide guidance on germline genetic testing in children with cancer. Regular review of these recommendations is essential. Collaboration and the use of data sharing platforms can further improve screening procedures and its impact on care.
•Screen all children with cancer clinically for predisposition syndromes.•Assess comprehensive germline gene testing for all children with cancer scientifically.•Consider upfront focused germline gene testing to support cancer diagnosis/treatment.•Inform patients/parents in advance about implications of genetic testing.•Consequences of predisposition syndrome identification need to be further assessed. |
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AbstractList | Cancer Predisposition Syndromes (CPSs) have been identified in 7–15 % of children with cancer. The possibilities for germline genetic testing have increased in recent years, presenting new opportunities but also challenges. There is currently no consensus on germline genetic testing in children with cancer in diagnostic settings.
The International Society of Pediatric Oncology Europe (SIOPE) Host Genome Working Group used a consensus development conference method to reach agreement on four key topics: Who do we test? Which genes do we test? What do we disclose? How do we evaluate the benefits of testing?
The Working Group members agreed that: (1) All children with cancer should undergo clinical screening for their risk of harboring a CPS. (2) Targeted genetic testing based on clinical indication is recommended. Comprehensive CPS gene panels with more than 100–150 genes for all children with cancer should preferably be evaluated within research settings. (3) Smaller actionable gene panels can be considered including genes supporting diagnosis or influencing treatment decisions. (4) Clear pre-test information and consenting processes that highlight potential outcomes and implications of germline genetic testing are imperative. (5) Consequences of genetic testing, treatment adaption, and tumor surveillance in children with CPSs, including economic impact and psychosocial factors, should be further explored.
These consensus-based recommendations provide guidance on germline genetic testing in children with cancer. Regular review of these recommendations is essential. Collaboration and the use of data sharing platforms can further improve screening procedures and its impact on care.
•Screen all children with cancer clinically for predisposition syndromes.•Assess comprehensive germline gene testing for all children with cancer scientifically.•Consider upfront focused germline gene testing to support cancer diagnosis/treatment.•Inform patients/parents in advance about implications of genetic testing.•Consequences of predisposition syndrome identification need to be further assessed. Background: Cancer Predisposition Syndromes (CPSs) have been identified in 7–15 % of children with cancer. The possibilities for germline genetic testing have increased in recent years, presenting new opportunities but also challenges. There is currently no consensus on germline genetic testing in children with cancer in diagnostic settings. Methods: The International Society of Pediatric Oncology Europe (SIOPE) Host Genome Working Group used a consensus development conference method to reach agreement on four key topics: Who do we test? Which genes do we test? What do we disclose? How do we evaluate the benefits of testing? Results: The Working Group members agreed that: (1) All children with cancer should undergo clinical screening for their risk of harboring a CPS. (2) Targeted genetic testing based on clinical indication is recommended. Comprehensive CPS gene panels with more than 100–150 genes for all children with cancer should preferably be evaluated within research settings. (3) Smaller actionable gene panels can be considered including genes supporting diagnosis or influencing treatment decisions. (4) Clear pre-test information and consenting processes that highlight potential outcomes and implications of germline genetic testing are imperative. (5) Consequences of genetic testing, treatment adaption, and tumor surveillance in children with CPSs, including economic impact and psychosocial factors, should be further explored. Conclusions: These consensus-based recommendations provide guidance on germline genetic testing in children with cancer. Regular review of these recommendations is essential. Collaboration and the use of data sharing platforms can further improve screening procedures and its impact on care. |
ArticleNumber | 100176 |
Author | Wadt, Karin A.W. Waespe, Nicolas Bourdeaut, Franck Kratz, Christian P. Jongmans, Marjolijn C.J. Bakhuizen, Jette J. |
Author_xml | – sequence: 1 givenname: Jette J. surname: Bakhuizen fullname: Bakhuizen, Jette J. organization: Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands – sequence: 2 givenname: Franck surname: Bourdeaut fullname: Bourdeaut, Franck organization: Paris-Cité University, SIREDO pediatric cancer center & INSERMU830, Institut Curie, Paris, France – sequence: 3 givenname: Karin A.W. surname: Wadt fullname: Wadt, Karin A.W. organization: Department of Clinical Genetics, Copenhagen University Hospital Righospitalet, Copenhagen, Denmark – sequence: 4 givenname: Christian P. surname: Kratz fullname: Kratz, Christian P. organization: Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany – sequence: 5 givenname: Marjolijn C.J. surname: Jongmans fullname: Jongmans, Marjolijn C.J. organization: Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands – sequence: 6 givenname: Nicolas surname: Waespe fullname: Waespe, Nicolas email: nicolas.waespe@unibe.ch organization: Division of Pediatric Hematology and Oncology, University Children’s Hospital Bern, Switzerland |
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Keywords | ACMG WGS WES Hereditary cancer CPS Cancer predisposition DICER1 Cancer screening Pediatric cancer MIPOGG VUS DNA Germline genetic Familial cancer SIOPE TP53 Genetic counselling |
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Snippet | Cancer Predisposition Syndromes (CPSs) have been identified in 7–15 % of children with cancer. The possibilities for germline genetic testing have increased in... Background: Cancer Predisposition Syndromes (CPSs) have been identified in 7–15 % of children with cancer. The possibilities for germline genetic testing have... |
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SubjectTerms | Cancer predisposition Cancer screening Familial cancer Genetic counselling Germline genetic Hereditary cancer Pediatric cancer |
Title | Genetic testing for childhood cancer predisposition syndromes: Controversies and recommendations from the SIOPE Host Genome Working Group meeting 2022 |
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