Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness

• Published in: The Journal of physiology Vol. 593; no. 17; p. 3899
• Main Authors: Sequeira, Vasco, Najafi, Aref, McConnell, Mark, Fowler, Ewan D, Bollen, Ilse A E, Wüst, Rob C I, dos Remedios, Cris, Helmes, Michiel, White, Ed, Stienen, Ger J M, Tardiff, Jil, Kuster, Diederik W D, van der Velden, Jolanda
• Format: Journal Article
• Language: English
• Published: England 01.09.2015
• Subjects: Actomyosin - physiology; Adenosine Diphosphate - physiology; Animals; Calcium - physiology; Cardiomyopathy, Dilated - physiopathology; Creatine Kinase - antagonists & inhibitors; Creatine Kinase - physiology; Diastole; Heart - physiology; Humans; Iodoacetamide - pharmacology; Isometric Contraction; Male; Myocytes, Cardiac - physiology; Rats, Wistar

Diastolic dysfunction in heart failure patients is evident from stiffening of the passive properties of the ventricular wall. Increased actomyosin interactions may significantly limit diastolic capacity, however, direct evidence is absent. From experiments at the cellular and whole organ level, in h...