Mathematical modelling of activation-induced heterogeneity in TNF, IL6, NOS2, and IL1β expression reveals cell state transitions underpinning macrophage responses to LPS

• Published in: Wellcome open research Vol. 7; p. 29
• Main Authors: Dey, Shoumit, Boucher, Dave, Pitchford, Jon, Lagos, Dimitris
• Format: Journal Article
• Language: English
• Published: Wellcome 01.07.2022
• Subjects: activation induced heterogeneity; eng; IL6; macrophage heterogeneity; mathematical modelling; NOS2; TNF

Background:  Despite extensive work on macrophage heterogeneity, the mechanisms driving activation induced heterogeneity (AIH) in macrophages remain poorly understood. Here, we aimed to develop mathematical models to explore theoretical cellular states underpinning the empirically observed responses...