Mechanically adaptive and deployable intracortical probes enable long-term neural electrophysiological recordings

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 40; p. e2403380121
• Main Authors: Wang, Suhao, Jiang, Qianqian, Liu, Hang, Yu, Chaonan, Li, Pengxian, Pan, Gang, Xu, Kedi, Xiao, Rui, Hao, Yaoyao, Wang, Chengjun, Song, Jizhou
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 01.10.2024
• Subjects: Animals; Brain; Brain - physiology; Cerebral Cortex - physiology; Configuration management; Design; Electrodes; Electrodes, Implanted; Electrophysiological Phenomena; Fabrication; Immune response; Immunological memory; Implantation; Mechanical properties; Neurons - physiology; Phase transitions; Polymers; Polymers - chemistry; Probes; Rats; Rats, Sprague-Dawley; Recording; Shape memory; Softening; Structural design; Structural engineering; Substrates; Tissues; neural probe; mechanically adaptive; shape memory polymer; deployable structure

Flexible intracortical probes offer important opportunities for stable neural interfaces by reducing chronic immune responses, but their advances usually come with challenges of difficult implantation and limited recording span. Here, we reported a mechanically adaptive and deployable intracortical...