Protective effect of apoptosis signal-regulating kinase1 inhibitor against mice liver injury

• Published in: 亚太热带医药杂志（英文版） Vol. 9; no. 3; pp. 278 - 282
• Main Author: Ping He Bo Zeng Xiao-Li Zhang Dian-Liang Fang Xia-Qia Zhou Ke-Qiang Wan Wen-Guang Tian
• Format: Journal Article
• Language: English
• Published: Department of Gastroenterology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China%Department of Infectious Diseases, Yongchuan Hospital of Chongqing Medical University, Chongqing, China 01.03.2016
• Subjects: 1;Acetaminophen;Liver; Apoptosis; injury;JNK; kinase; signal-regulating; Apoptosis signal-regulating kinase 1; Acetaminophen; JNK; Liver injury

Objective:To explore the protective effect and its molecular mechanism of apoptosis signalregulating kinase 1(ASK1) inhibitor(GS-459679) on acetaminophen-induced liver injury in mice.Methods:The model of liver injury was established by administration of acetaminophen(APAP)(300 mg/kg,i.p.) on C57BL/6...