The role of p75NTR in cholinergic basal forebrain structure and function

• Published in: The Journal of neuroscience Vol. 34; no. 39; pp. 13033 - 13038
• Main Authors: Boskovic, Zoran, Alfonsi, Fabienne, Rumballe, Bree A, Fonseka, Sachini, Windels, Francois, Coulson, Elizabeth J
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 24.09.2014
• Subjects: Animals; Brief Communications; Cholinergic Neurons - metabolism; Cholinergic Neurons - physiology; Cognition; Female; Male; Maze Learning; Mice; Mice, Inbred C57BL; Prosencephalon - cytology; Prosencephalon - growth & development; Prosencephalon - metabolism; Prosencephalon - physiology; Receptors, Nerve Growth Factor - genetics; Receptors, Nerve Growth Factor - metabolism; Synaptic Transmission; navigation; Morris water maze; cholinergic basal forebrain; hippocampus; knock-out; p75 neurotrophin receptor

The role of the p75 neurotrophin receptor (p75(NTR)) in adult cholinergic basal forebrain (cBF) neurons is unclear due to conflicting results from previous studies and to limitations of existing p75(NTR)-knock-out mouse models. In the present study we used a novel conditional knock-out line (ChAT-cr...