Orbital Venous Malformation

[...]infections are common in the orbital and periorbital regions but are rarely confused with a vascular lesion due to the associated clinical features. In a minority of patients, a mutation in the TIE-2 gene has been identified, linking 1.2% of VMs to genetic causes.1,2 Venous malformations involv...

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Published inApplied radiology (1976) Vol. 49; no. 2; pp. 48 - 48C
Main Authors Kent, Amy, Towbin, Richard, Schaefer, Carrie, Kaye, Robin, Jorgensen, Scott, Abruzzo, Todd, Towbin, Alexander, Aria, David
Format Journal Article
LanguageEnglish
Published Scotch Plains Anderson Publishing Ltd 01.03.2020
Subjects
Biopsy
Blindness
Children & youth
Deformation mechanisms
Endothelial cells
Ethanol
Lipids
Mutation
Necrosis
Pulmonary fibrosis
Sclerotherapy
Thrombosis
Tumors
Ultrasonic imaging
Water chemistry
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Summary:[...]infections are common in the orbital and periorbital regions but are rarely confused with a vascular lesion due to the associated clinical features. In a minority of patients, a mutation in the TIE-2 gene has been identified, linking 1.2% of VMs to genetic causes.1,2 Venous malformations involving the face may distend with Valsalva maneuver or positioning the child in a head-down dependent position and can cause deformity, asymmetry, exopthalmus and dental problems. Upon injection, ethanol displaces water molecules and penetrates the lipid bilayer of the cells, which compromises the stable membrane and kills the endothelial cells.3,4 Potential complications with ethanol sclerotherapy include nerve injury with sensory loss and blindness in or around the treated eye, cavernous sinus thrombosis, skin necrosis, renal failure, and cardiopulmonary failure.
ISSN:1879-2898
0160-9963
1879-2898
DOI:10.37549/AR2639