A Case of Hyperammonemic Encephalopathy after Modified FOLFOX6 Regimen for Metastatic Colon Cancer

5-Fluorouracil and leucovorin with oxaliplatin (FOLFOX) or irinotecan (FOLFIRI) therapy are commonly-used chemotherapy regimens for metastatic colorectal cancer. Hyperammonemic encephalopathy is a relatively rare adverse event of chemotherapy using 5-FU. Herein, we report a case of hyperammonemic en...

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Published inNippon Daicho Komonbyo Gakkai Zasshi Vol. 64; no. 7; pp. 467 - 470
Main Authors Shomura, Hiroki, Nakano, Shiro, Inagaki, Mitsuhiro, Yanagida, Naoyuki, Kudo, Takeaki, Orimo, Tatsuya, Oikawa, Futoshi, Yoneya, Risa
Format Journal Article
LanguageEnglish
Japanese
Published The Japan Society of Coloproctology 2011
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Abstract 5-Fluorouracil and leucovorin with oxaliplatin (FOLFOX) or irinotecan (FOLFIRI) therapy are commonly-used chemotherapy regimens for metastatic colorectal cancer. Hyperammonemic encephalopathy is a relatively rare adverse event of chemotherapy using 5-FU. Herein, we report a case of hyperammonemic encephalopathy after modified FOLFOX6 regimen for a patient with metastatic colon cancer. A 30-year-old female was diagnosed with appendix cancer with liver and peritoneum dissemination. She was treated with modified FOLFOX6 therapy. She showed confusion on treatment day 3 of the fifth cycle of FOLFOX therapy. Laboratory examination revealed her serum ammonia level to be 503μg/dl. We diagnosed 5-FU-induced hyperammonemia, and treated her with branched-chain amino acid solutions. Her consciousness improved during that night.
AbstractList 5-Fluorouracil and leucovorin with oxaliplatin (FOLFOX) or irinotecan (FOLFIRI) therapy are commonly-used chemotherapy regimens for metastatic colorectal cancer. Hyperammonemic encephalopathy is a relatively rare adverse event of chemotherapy using 5-FU. Herein, we report a case of hyperammonemic encephalopathy after modified FOLFOX6 regimen for a patient with metastatic colon cancer. A 30-year-old female was diagnosed with appendix cancer with liver and peritoneum dissemination. She was treated with modified FOLFOX6 therapy. She showed confusion on treatment day 3 of the fifth cycle of FOLFOX therapy. Laboratory examination revealed her serum ammonia level to be 503μg/dl. We diagnosed 5-FU-induced hyperammonemia, and treated her with branched-chain amino acid solutions. Her consciousness improved during that night.
Author Kudo, Takeaki
Oikawa, Futoshi
Nakano, Shiro
Yanagida, Naoyuki
Orimo, Tatsuya
Yoneya, Risa
Shomura, Hiroki
Inagaki, Mitsuhiro
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Cites_doi 10.1016/j.anl.2007.04.012
10.1097/00001813-199903000-00004
10.1093/jjco/hye130
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Title A Case of Hyperammonemic Encephalopathy after Modified FOLFOX6 Regimen for Metastatic Colon Cancer
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