Challenges and Opportunities in the Application of CRISPR-Cas9: A Review on Genomic Editing and Therapeutic Potentials

• Published in: Medical principles and practice pp. 1 - 30
• Main Authors: Karimi, Mohammad Ali, Paryan, Mahdiesadat, Behrouzian Fard, Ghazaleh, Sadeghian, Hamid, Zarrinfar, Hossein, Hosseini Bafghi, Mahdi
• Format: Journal Article
• Language: English
• Published: Switzerland 17.07.2025
• Subjects: Off-target effects; Genetic engineering; Gene therapy; CRISPR-Cas9; Gene editing

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and the CRISPR-associated protein 9 (Cas9) constitute a revolutionary gene-editing technology, allowing precise DNA modifications with vast potential for disease treatment and the creation of genetically modified organisms. This syst...