In Vivo Self‐Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization

• Published in: Angewandte Chemie Vol. 133; no. 47; pp. 25332 - 25338
• Main Authors: Guo, Ruo‐Chen, Zhang, Xue‐Hao, Fan, Peng‐Sheng, Song, Ben‐Li, Li, Zhi‐Xiang, Duan, Zhong‐Yu, Qiao, Zeng‐Ying, Wang, Hao
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 15.11.2021
• Subjects: Alkaline phosphatase; Assembly; cancer; Cell membranes; Chemistry; Drug delivery; Internalization; Lipids; Membranes; peptide; Peptides; Phase separation; self-assembly

Therapeutic peptides have been widely concerned, but their efficacy is limited by the inability to penetrate cell membranes, which is a key bottleneck in peptide drugs delivery. Herein, an in vivo self‐assembly strategy is developed to induce phase separation of cell membrane that improves the pepti...