Cobalt‐Catalyzed Intramolecular Markovnikov Hydrocarbonylation of Unactivated Alkenes via Hydrogen Atom Transfer

• Published in: Angewandte Chemie Vol. 136; no. 46
• Main Authors: Jiang, Donghao, Li, Xinzhu, Xiao, Mengdie, Cheng, Li‐Jie
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 11.11.2024
• Subjects: Alkenes; Alkylation; Chemical synthesis; Cobalt; Functional groups; Hydrocarbonylation; Hydrogen Atom Transfer; Hydrogen atoms; Lactones; Markovnikov Selectivity; Unactivated Alkenes

A cobalt‐catalyzed intramolecular Markovnikov hydroalkoxycarbonylation and hydroaminocarbonylation of unactivated alkenes has been developed, enabling highly chemo‐ and regioselective synthesis of α‐alkylated γ‐lactones and α‐alkylated γ‐lactams in good yields. The mild reaction conditions allow use...