PAI-1 induction is a critical event for the onset of lipopolysaccharide-induced acute kidney injury

• Published in: Proceedings for Annual Meeting of The Japanese Pharmacological Society Vol. 96; p. 1-B-P-046
• Main Authors: Koki, Tanaka, Obana, Masanori, Sakai, Hibiki, Kamuro, Hiroyasu, Yamamoto, Ayaha, Tanaka, Syota, Okada, Yoshiaki, Fujio, Yasushi
• Format: Journal Article
• Language: Japanese; English
• Published: Japanese Pharmacological Society 2022

【Background】A systemic inflammatory response caused by sepsis leads to widespread organ dysfunction, including acute kidney injury. However, the pathogenetic mechanisms of acute kidney injury（AKI） in sepsis remain fully elucidated. Recently, it has been reported that plasminogen activator inhibitor-...