Synthesis of Axially Chiral N‐Arylindoles via Atroposelective Cyclization of Ynamides Catalyzed by Chiral Brønsted Acids

• Published in: Angewandte Chemie Vol. 134; no. 20
• Main Authors: Wang, Ze‐Shu, Zhu, Lu‐Jing, Li, Cui‐Ting, Liu, Bin‐Yang, Hong, Xin, Ye, Long‐Wu
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 09.05.2022
• Subjects: Alkynes; Asymmetry; Axial Chirality; Brønsted Acids; Catalysis; Chemistry; Chirality; Heterocycles; Organocatalysis

In recent years, asymmetric catalysis of ynamides has attracted much attention, but these reactions mostly constructed central chirality, except for a few examples on the synthesis of axially chiral compounds which exclusively relied on noble‐metal catalysis. Herein, a facile access to axially chira...