Enantioselective para‐C(sp2)−H Functionalization of Alkyl Benzene Derivatives via Cooperative Catalysis of Gold/Chiral Brønsted Acid

• Published in: Angewandte Chemie Vol. 134; no. 40
• Main Authors: Liu, Xun‐Shen, Tang, Zhiqiong, Si, Zhi‐Yao, Zhang, Zhikun, Zhao, Lei, Liu, Lu
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 04.10.2022
• Subjects: Arenes; Benzene; Catalysis; Chemistry; Cooperative Catalysis; C−H Bond Insertion; Diazo Compounds; Enantiomers; Gold; Hydrogen bonds; Molecular sieves; Phosphoric acid; Site-Selective; Substrates

An asymmetric para‐C(sp2)−H bond functionalization of alkyl benzene derivatives was successfully developed via cooperative catalysis of gold and chiral phosphoric acid (CPA), leading to synthetically useful chiral 1,1‐diaryl motifs. Chiral phosphoric acid, ligand, and molecular sieves were found to...